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Radiosensitivity of hepatoma cell lines and human normal liver cell lines exposed in vitro to carbon ions and argon ions at the HIRFL

文献类型：期刊论文

作者Jing, Xigang1,2; Li, Wenjian1; Wang, Zhuanzi1; Wei, Wei1; Guo, Chuanling1; Lu, Dong1,2; Yang, Jianshe3
刊名NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
出版日期2009-05-15
卷号267期号:10页码:1837-1840
关键词Heavy ion Human normal liver cell lines Hepatoma cell lines Radiotherapy
ISSN号0168-583X
DOI10.1016/j.nimb.2009.03.004
英文摘要Human hepatoma (SMMC-7721) and normal liver (L02) cells were irradiated with gamma-rays, (12)C(6+) and (36)Ar(18+) ion beams at the Heavy Ion Research Facility in Lanzhou (HIRFL). By using the Calyculin-A induced premature chromosome condensation technique, chromatid-type breaks and isochromatid-type breaks were scored separately. Tumor cells irradiated with heavy ions produced a majority of isochromatid break, while chromatid breaks were dominant when cells were exposed to gamma-rays. The relative biological effectiveness (RBE) for irradiation-induced chromatid breaks were 3.6 for L02 and 3.5 for SMMC-7721 cell lines at the LET peak of 96 keV mu m(-1) (12)C(6+) ions, and 2.9 for both of the two cell lines of 512 keV mu m(-1) (36)Ar(18+) ions. It suggested that the RBE of isochromatid-type breaks was pretty high when high-LET radiations were induced. Thus we concluded that the high production of isochromatid-type breaks, induced by the densely ionizing track structure, could be regarded as a signature of high-LET radiation exposure. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
WOS关键词PREMATURE CHROMOSOME CONDENSATION ; HUMAN FIBROBLASTS ; INTRINSIC RADIOSENSITIVITY ; ALPHA-PARTICLES ; HEAVY-IONS ; GAMMA-RAYS ; RADIATION ; ABERRATIONS ; CHROMATIN ; RADIOTHERAPY
资助项目National Natural Science Foundation of China ; National Basic Research Program of China[10335050] ; National Basic Research Program of China[2003CCB00200]
WOS研究方向Instruments & Instrumentation ; Nuclear Science & Technology ; Physics
语种英语
WOS记录号WOS:000266759900016
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China ; National Basic Research Program of China
公开日期2010-10-29
源URL[http://ir.imp.cas.cn/handle/113462/5243]  
专题近代物理研究所_近代物理研究所知识存储（2010之前）
近代物理研究所_生物物理研究室
通讯作者Jing, Xigang
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Gansu, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.NW Normal Univ, Sch Life Sci, Lanzhou, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Jing, Xigang,Li, Wenjian,Wang, Zhuanzi,et al. Radiosensitivity of hepatoma cell lines and human normal liver cell lines exposed in vitro to carbon ions and argon ions at the HIRFL[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2009,267(10):1837-1840.
APA Jing, Xigang.,Li, Wenjian.,Wang, Zhuanzi.,Wei, Wei.,Guo, Chuanling.,...&Yang, Jianshe.(2009).Radiosensitivity of hepatoma cell lines and human normal liver cell lines exposed in vitro to carbon ions and argon ions at the HIRFL.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,267(10),1837-1840.
MLA Jing, Xigang,et al."Radiosensitivity of hepatoma cell lines and human normal liver cell lines exposed in vitro to carbon ions and argon ions at the HIRFL".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 267.10(2009):1837-1840.

入库方式： OAI收割

来源：近代物理研究所

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