Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water
文献类型：期刊论文
| 作者 | Wang, Z. Z.1; Li, W. J.1; Zhi, D. J.2; Qu, Y.1 ; Jing, X. G.1
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| 刊名 | NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 267期号:15页码:2521-2524 |
| 关键词 | Carbon ions Micronuclei Depth of ions in water |
| ISSN号 | 0168-583X |
| DOI | 10.1016/j.nimb.2009.06.007 |
| 英文摘要 | Here we used cytokinesis-block micronucleus assay to measure the biological response along the penetrate depth of ions in water in human lymphocytes exposed to 100 MeV/u incident carbon ions in vitro. Polyethylene shielding was used to change the penetration depth of ions in water. A quantitative biological response curve was generated for micronuclei induction. The results showed a marked increase with the penetrate depth of ions in water in the micronuclei formation, which was consistent with a linear-energy-transfer dependent increase in biological effectiveness. The dose-response relationship for MN information was different at different penetrate depth of ions in water, at the 6 and 11.2 mm penetrate depth of ions in water, the dose-response relationships for the micronucleus frequencies induced by carbon ions irradiation were linear; while it was power function at 17.1 mm penetrate depth. (C) 2009 Elsevier B.V. All rights reserved. |
| WOS关键词 | CHROMOSOME-ABERRATIONS ; RADIATION ; CELLS ; ASSAY ; IRRADIATION ; THERAPY ; REGION ; DAMAGE ; BEAMS ; BLOCK |
| 资助项目 | Talent Training Program for Young Scientist (PhD) in West China of the Chinese Academy of Sciences ; Chinese Academy of Sciences for Postgraduate students ; National Nature Science Foundation of China[10875153] |
| WOS研究方向 | Instruments & Instrumentation ; Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000268617300010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | Talent Training Program for Young Scientist (PhD) in West China of the Chinese Academy of Sciences ; Chinese Academy of Sciences for Postgraduate students ; National Nature Science Foundation of China |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5245]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） 近代物理研究所_生物物理研究室 |
| 通讯作者 | Wang, Z. Z. |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Radiobiol Lab, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Inst Pharmaceut, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Z. Z.,Li, W. J.,Zhi, D. J.,et al. Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2009,267(15):2521-2524. |
| APA | Wang, Z. Z.,Li, W. J.,Zhi, D. J.,Qu, Y.,&Jing, X. G..(2009).Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,267(15),2521-2524. |
| MLA | Wang, Z. Z.,et al."Micronuclei induction in human lymphocytes induced by carbon ions exposion along the penetrate depth of ions in water".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 267.15(2009):2521-2524. |
入库方式： OAI收割
来源：近代物理研究所
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