A new potential radiosensitizer- multi-walled carbon nanotubes modified by ammonium persulfate
文献类型：期刊论文
| 作者 | Yang, Jian-She1,2; Jing, Xigang2 ; Li, Wen-Jian2; Hu, Xiang-Kai2; Wei, Wei2; Wang, Zhuan-Zi2
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| 刊名 | GENE THERAPY AND MOLECULAR BIOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 12B页码:247-252 |
| 关键词 | ammonium persulfate multi-walled carbon nanotubes |
| ISSN号 | 1529-9120 |
| 英文摘要 | Here we prepare carbon nanotubes modified with ammonium persulfate, very short carbon nanotubes with 50-100 nanometer length was obtained, and the higher Z potential of 52 mV was detected, these supporting the successful modification. HeLa cells were irradiated with gamma rays via adding or absent above functionalized carbon nanotubes (f-WCNTs) into cell culture medium with different concentration and radiation dosage. Confocal microscopy images and fluorescence-labeled DNA detection verified the successfully pure multi-wailed carbon nanotubes (p-WCNTs) and f-WCNTs penetrated into cells. Compared with pure radiation, by MTT test, f-WCNTs induced cell death markedly with about 8.7 times higher than former one under little dose of radiation; meanwhile, no obvious toxicity was observed both in p-WCNTs and f-WCNTs without of radiation exposure. We hypothesized that large amount of hydroxyl and carbonyl organs on the surface of very short f-WCNTs changed into free radicals result from radiations led cell damage. These implied that f-WCNTs could be regarded as a new radiosensitizer. |
| WOS关键词 | ENDOCYTOSIS ; PEPTIDES ; GROWTH |
| 资助项目 | MOST[2006CB705600] ; National Natural Science Foundation[10475109] ; K. C. Wong Education Foundation, Hong Kong[20060037] ; China Postdoctoral Science Foundation[20060400686] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000265623400010 |
| 出版者 | GENE THERAPY PRESS |
| 资助机构 | MOST ; National Natural Science Foundation ; K. C. Wong Education Foundation, Hong Kong ; China Postdoctoral Science Foundation |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5383]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） 近代物理研究所_生物物理研究室 |
| 通讯作者 | Yang, Jian-She |
| 作者单位 | 1.NW Normal Univ, Sch Life Sci, Lanzhou 730070, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jian-She,Jing, Xigang,Li, Wen-Jian,et al. A new potential radiosensitizer- multi-walled carbon nanotubes modified by ammonium persulfate[J]. GENE THERAPY AND MOLECULAR BIOLOGY,2008,12B:247-252. |
| APA | Yang, Jian-She,Jing, Xigang,Li, Wen-Jian,Hu, Xiang-Kai,Wei, Wei,&Wang, Zhuan-Zi.(2008).A new potential radiosensitizer- multi-walled carbon nanotubes modified by ammonium persulfate.GENE THERAPY AND MOLECULAR BIOLOGY,12B,247-252. |
| MLA | Yang, Jian-She,et al."A new potential radiosensitizer- multi-walled carbon nanotubes modified by ammonium persulfate".GENE THERAPY AND MOLECULAR BIOLOGY 12B(2008):247-252. |
入库方式： OAI收割
来源：近代物理研究所
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