Alterations of immune functions induced by 12C6+ion irradiation in mice
文献类型：期刊论文
| 作者 | Qiu, R.; Yuan, Z. G.; Zhou, G. M.; Xie, Y.; Zhang, H. ; Wang, Y. L.; Zhou, Q. M.
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| 刊名 | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 83期号:9页码:577-581 |
| 关键词 | 12C6+heavy ion NK cell activity IFN-gamma level thymus spleen mice |
| ISSN号 | 0955-3002 |
| DOI | 10.1080/09553000701481774 |
| 英文摘要 | Purpose: To estimate the biological risks to the immune system of the type of space radiation, 12C6+, encountered by cosmonauts during long-term travel in space. Materials and methods: The Kun-Ming strain mice were whole-body irradiated by 12C6+ ion with 0, 0.01, 0.05, 0.075, 0.2, 0.3, 0.5, 0.75, 1 or 2 Gy, at a dose rate of 1 Gy/min. At 35 days after irradiation, the thymus and spleen weights were measured, the natural killer (NK) cells activity of spleen was determined by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), and the interferon-gamma (IFN-gamma) levels in serum and thymus were detected with enzyme-linked immunosorbent assays (ELISA). Results: The results showed that the thymus weight, IFN-gamma levels in serum and the activity of splenic NK-cells had significantly increased at a dose of 0.05 Gy. With further dose increase, the weight of spleen continued to increase but the weight of thymus, IFN-gamma level and NK-cells activity declined. Conclusions: These results suggest that the dose of 0.05 Gy irradiation has a stimulatory effect on mouse immunity; this effect declined with increasing dose. |
| WOS关键词 | CYTOGENETIC ADAPTIVE RESPONSE ; LOW-DOSE RADIATION ; NATURAL-KILLER-CELLS ; NK CELLS ; PROTEIN EXPRESSION ; GAMMA-RADIATION ; GERM-CELLS ; IFN-GAMMA ; INFECTION ; INDUCTION |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Nuclear Science & Technology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000248334500002 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5487]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Zhang, H. |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Radiol, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, R.,Yuan, Z. G.,Zhou, G. M.,et al. Alterations of immune functions induced by 12C6+ion irradiation in mice[J]. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,2007,83(9):577-581. |
| APA | Qiu, R..,Yuan, Z. G..,Zhou, G. M..,Xie, Y..,Zhang, H..,...&Zhou, Q. M..(2007).Alterations of immune functions induced by 12C6+ion irradiation in mice.INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,83(9),577-581. |
| MLA | Qiu, R.,et al."Alterations of immune functions induced by 12C6+ion irradiation in mice".INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 83.9(2007):577-581. |
入库方式： OAI收割
来源：近代物理研究所
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