NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death
文献类型：期刊论文
| 作者 | Liu, Qing2,3; He, Xiaoqing4; Liu, Yongsheng5; Du, Bingbing6; Wang, Xiaoyan6; Zhang, Weisheng7; Jia, Pengfei1; Dong, Jingmei8; Ma, Jianxiu9; Wang, Xiaohu10 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2008-12-19 |
| 卷号 | 377期号:3页码:775-779 |
| 关键词 | NADPH oxidase New mechanism X-ray irradiation HeLa cell death |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2008.10.067 |
| 英文摘要 | Oxidative damage is an important mechanism in X-ray-induced cell death. Radiolysis of water molecules is a source of reactive oxygen species (ROS) that contribute to X-ray-induced cell death. In this study, we showed by ROS detection and a cell survival assay that NADPH oxidase has a very important role in X-ray-induced cell death. Under X-ray irradiation, the upregulation of the expression of NADPH oxidase membrane Subunit gp91(phox) was dose-dependent. Meanwhile, the cytoplasmic subunit p47(phox) was translocated to the cell membrane and localized with p22(phox) and gp91(phox) to form reactive NADPH oxidase. Our data Suggest, for the first time, that NADPH oxidase-mediated generation of ROS is an important contributor to X-ray-induced cell death. This suggests a new target for combined gene transfer and radiotherapy. (C) 2008 Elsevier Inc. All rights reserved. |
| WOS关键词 | OXIDATIVE STRESS ; MAMMALIAN-CELLS ; IN-VITRO ; RADIOSENSITIZATION ; CARCINOMA ; ACTIVATION ; EXPRESSION |
| 资助项目 | National Natural Science Foundation of China[10675151] ; National Natural Science Foundation of China[30870586] ; Postdoctoral Foundation of China[20070410232] ; Lanzhou Prajna Union Biology Technique Co., Ltd |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000261458900008 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 资助机构 | National Natural Science Foundation of China ; Postdoctoral Foundation of China ; Lanzhou Prajna Union Biology Technique Co., Ltd |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5521]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Lanzhou Univ, Sch Life Sci, Inst Cell Biol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Radiobiol, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Lanzhou Univ, Affiliated Hosp 1, Lanzhou 730000, Peoples R China 5.Chinese Acad Agr, Lanzhou Vet Res Inst, Minist Agr, Key Lab Anim Virol, Lanzhou 730046, Peoples R China 6.Lanzhou Univ, Coll Med, Lanzhou 730000, Peoples R China 7.Gansu Prov Peoples Hosp, Lanzhou 730000, Peoples R China 8.Lanzhou City Univ, Inst Sports Med, Lanzhou 730070, Peoples R China 9.NW Univ Nationalities, Coll Med, Lanzhou 730030, Peoples R China 10.Gansu Prov Canc Hosp, Dept Radiol, Lanzhou 730050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qing,He, Xiaoqing,Liu, Yongsheng,et al. NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,377(3):775-779. |
| APA | Liu, Qing.,He, Xiaoqing.,Liu, Yongsheng.,Du, Bingbing.,Wang, Xiaoyan.,...&Zhang, Hong.(2008).NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,377(3),775-779. |
| MLA | Liu, Qing,et al."NADPH oxidase-mediated generation of reactive oxygen species: A new mechanism for X-ray-induced HeLa cell death".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377.3(2008):775-779. |
入库方式： OAI收割
来源：近代物理研究所
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