The influence of fractionation on cell survival and premature differentiation after carbon ion irradiation
文献类型：期刊论文
| 作者 | Wang, Jufang1 ; Li, Renming3; Guo, Chuanling3; Fournier, Claudia2; K-Weyrather, Wilma2
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| 刊名 | JOURNAL OF RADIATION RESEARCH
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| 出版日期 | 2008 |
| 卷号 | 49期号:4页码:391-398 |
| 关键词 | Human-skin Fibroblasts Subcutaneous Fibrosis Heavy-ions Gamma-rays Radiotherapy Mechanisms Cultures Therapy Repair Beams |
| ISSN号 | 0449-3060 |
| DOI | 10.1269/jrr.08012 |
| 英文摘要 | Carbon ion radiotherapy/Fractionated irradiation/R-BE/Premature terminal differentiation. To investigate the influence of fractionation on cell survival and radiation induced premature differentiation as markers for early and late effects after X-rays and carbon irradiation. Normal human fibroblasts NHDF, AG1522B and WI-38 were irradiated With 250 kV X-rays, or 266 MeV/u, 195 MeV/u and I I MeV/u carbon ions. Cytotoxicity was measured by a clonogenic survival assay or by determination of the differentiation pattern. Experiments with high-energy carbon ions show that fractionation induced repair effects are similar to photon irradiation. The RBE10 values for clonogenic survival are 1.3 and 1.6 for irradiation in one or two fractions for NHDF cells and around 1.2 for AG1522B cells regardless of the fractionation scheme. The RBE for a doubling of post mitotic fibroblasts (PMF) in the population is I for both single and two fractionated irradiation of NHDF cells. Using I I MeV/u carbon ions, no repair effect can be seen in WI-38 cells. The RBE10 for clonogenic survival is 3.2 for single irradiation and 4.9 for two fractionated irradiations. The RBE for a doubling of PMF is 3.1 and 5.0 for single and two fractionated irradiations, respectively. For both cell lines the effects of high-energy carbon ions representing the irradiation of the skin and the normal tissue in the entrance channel are similar to the effects of X-rays. The fractionation effects are maintained. For the lower energy, which is representative for the irradiation of the tumor region. RBE is enhanced for clonogenic survival as well as for premature terminal differentiation. Fractionation effects are not detectable. Consequently, the therapeutic ratio is significantly enhanced by fractionated irradiation with carbon ions. |
| WOS关键词 | HUMAN-SKIN FIBROBLASTS ; SUBCUTANEOUS FIBROSIS ; HEAVY-IONS ; GAMMA-RAYS ; RADIOTHERAPY ; MECHANISMS ; CULTURES ; THERAPY ; REPAIR ; BEAMS |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000259337400007 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | GSI, Germany |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5617]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） 近代物理研究所_生物物理研究室 |
| 通讯作者 | Wang, Jufang |
| 作者单位 | 1.Chinese Acad Sci, IMP, Lanzhou 730000, Peoples R China 2.GSI Biophys, D-64291 Darmstadt, Germany 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jufang,Li, Renming,Guo, Chuanling,et al. The influence of fractionation on cell survival and premature differentiation after carbon ion irradiation[J]. JOURNAL OF RADIATION RESEARCH,2008,49(4):391-398. |
| APA | Wang, Jufang,Li, Renming,Guo, Chuanling,Fournier, Claudia,&K-Weyrather, Wilma.(2008).The influence of fractionation on cell survival and premature differentiation after carbon ion irradiation.JOURNAL OF RADIATION RESEARCH,49(4),391-398. |
| MLA | Wang, Jufang,et al."The influence of fractionation on cell survival and premature differentiation after carbon ion irradiation".JOURNAL OF RADIATION RESEARCH 49.4(2008):391-398. |
入库方式： OAI收割
来源：近代物理研究所
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