The experimental measurement of the relative biological effectiveness of carbon ions with different qualities
文献类型：期刊论文
| 作者 | Wang Jufang; Li Wenjian |
| 刊名 | PLASMA SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2008-06-01 |
| 卷号 | 10期号:3页码:387-390 |
| 关键词 | carbon ions relative biological effectiveness measurement |
| ISSN号 | 1009-0630 |
| 英文摘要 | The relative biological effectiveness (RBE) of carbon ions with linear energy transfer (LET) of 172 keV/mu m and 13.7 keV/mu m were determined in this study. The clonogenic survival and premature terminal differentiation were measured on normal human. broblasts AG01522C and NHDF after exposure of the cells to 250 kV X-rays and carbon ions with different qualities. RBE was determined for these two biological end points. The results showed that the measured RBE10 with a survival fraction of 10% was 3.2 for LET 172 keV/mu m, and 1.33 for LET 13.7 keV/mu m carbon ions. RBE for a doubling of post-mitotic. broblasts (PMF) in the population was 2.8 for LET 172 keV/mu m, and 1 for LET 13.7 keV/mu m carbon ions. For the carbon ion therapy, a high RBE value on the Bragg peak results in a high biological dose on the tumour. The tumour cells can be killed effectively. At the same time, the dose on healthy tissue would be reduced accordingly. This will lighten the late effect such as fibrosis on normal tissue. |
| WOS关键词 | IRRADIATION ; FIBROBLASTS ; FIBROSIS ; RADIOTHERAPY ; THERAPY ; INVITRO ; CELLS ; RBE |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000257200900024 |
| 出版者 | IOP PUBLISHING LTD |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5667]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Wang Jufang |
| 作者单位 | Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Jufang,Li Wenjian. The experimental measurement of the relative biological effectiveness of carbon ions with different qualities[J]. PLASMA SCIENCE & TECHNOLOGY,2008,10(3):387-390. |
| APA | Wang Jufang,&Li Wenjian.(2008).The experimental measurement of the relative biological effectiveness of carbon ions with different qualities.PLASMA SCIENCE & TECHNOLOGY,10(3),387-390. |
| MLA | Wang Jufang,et al."The experimental measurement of the relative biological effectiveness of carbon ions with different qualities".PLASMA SCIENCE & TECHNOLOGY 10.3(2008):387-390. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。