Effect of 80.55 MeV/u(12)C(6+) ions on radiosensitivity and cell cycle of human hepatoma cell lines
文献类型：期刊论文
| 作者 | WEI Wei1,2 ; LI Wenjian2; GUO Chuanling1,2; JING Xigang2; JIN Xiaodong1,2; SU Xu3
|
| 刊名 | PLASMA SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2008-04-01 |
| 卷号 | 10期号:2页码:245-249 |
| 关键词 | heavy ions human hepatoma cell lines radiosensitivity cell cycle cell apoptosis |
| ISSN号 | 1009-0630 |
| 英文摘要 | In this paper, the relationship between radiosensitivity, cell cycle alteration and the change of apoptosis in different human hepatoma cell lines irradiated by heavy ions were studied with the aim of building up the base data for clinical therapy. Exponentially growing hepatoma cell lines were irradiated by 80.55 MeV/u(12)C(6+) ions at a dose of 0 Gy, 0.5 Gy, 1 Gy, 2 Gy, 4 Gy and 8 Gy. The radiosensitivity was assessed by means of the colony-forming assay. The DNA content, the percentage of each cell-cycle phase and the apoptosis rate were obtained with flow cytometry methods. After the irradiation, the SF(2) (survival fraction at 2 gray) of SMMC-7721 cells were evidently lower than that of HepG2 cells. The S phase arrest, G2/M phase arrest delay and the apoptosis in the two hepatoma cell lines varied with the increase of the dose and repair time. The heavy ions could obviously kill the human hepatoma cell lines. Compared to HepG2 cells, SMMC-7721 cells were more radiosensitive to (12)C(6+) ions. |
| WOS关键词 | FLOW-CYTOMETRY ; APOPTOSIS ; EXPOSURE ; REPAIR |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000255120200022 |
| 出版者 | IOP PUBLISHING LTD |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5669]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） 近代物理研究所_生物物理研究室 |
| 通讯作者 | WEI Wei |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Natl Inst Radiol Protect, Beijing 10008, Peoples R China |
| 推荐引用方式 GB/T 7714 | WEI Wei,LI Wenjian,GUO Chuanling,et al. Effect of 80.55 MeV/u(12)C(6+) ions on radiosensitivity and cell cycle of human hepatoma cell lines[J]. PLASMA SCIENCE & TECHNOLOGY,2008,10(2):245-249. |
| APA | WEI Wei,LI Wenjian,GUO Chuanling,JING Xigang,JIN Xiaodong,&SU Xu.(2008).Effect of 80.55 MeV/u(12)C(6+) ions on radiosensitivity and cell cycle of human hepatoma cell lines.PLASMA SCIENCE & TECHNOLOGY,10(2),245-249. |
| MLA | WEI Wei,et al."Effect of 80.55 MeV/u(12)C(6+) ions on radiosensitivity and cell cycle of human hepatoma cell lines".PLASMA SCIENCE & TECHNOLOGY 10.2(2008):245-249. |
入库方式： OAI收割
来源：近代物理研究所
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