Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice
文献类型：期刊论文
| 作者 | Liu, Yang; Zhang, Hong ; Zhang, Luwei; Zhou, Qingming; Wang, Xiaohu; Long, Jing; Dong, Tao; Zhao, Weiping
|
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 575期号:1--3页码:142-148 |
| ISSN号 | 0014-2999 |
| 关键词 | N-acetylcysteine reactive oxygen species X-ray mouse liver |
| DOI | 10.1016/j.ejphar.2007.07.026 |
| 英文摘要 | The aim of this study was to evaluate the protective effects of different doses and administration modes of N-acetylcysteine (NAC) against X-ray-induced liver damage in mice. Kun-Ming mice were divided into four groups, each composed of six animals: two control groups and two NAC-treated groups. An acute study was carried out to determine alterations in lipid peroxidation (determined by measuring malondiadehyde (MDA) level), glutathione (GSH) content and superoxide dismutase (SOD) activity (assayed by colorimetric method), and DNA damage (characterized by DNA-single strand break using with comet assay) as well as cell apoptosis (measured by flow cytometry) at 12 h after irradiation. The results showed that there were dose-related decreases in MDA level, DNA damage and cell apoptosis, and dose-dependent increases in GSH content and SOD activity in all NAC-treated groups compared to control groups, indicating that pre-treatment or post-treatment with NAC significantly attenuates the acute liver damage caused by X-ray. In addition, significant positive correlations were observed between MDA level and DNA damage or cell apoptosis, implying that lipid peroxidation plays a major role in X-ray-induced liver injury. The data suggest that NAC exerts its radioprotective effect by counteracting accumulated reactive oxygen species in the liver through its properties as a direct antioxidant and a GSH precursor, when administered before or after X-ray irradiation. (C) 2007 Elsevier B.V. All rights reserved. |
| WOS关键词 | INDUCED OXIDATIVE STRESS ; INDUCED DNA-DAMAGE ; COMET ASSAY ; IN-VITRO ; INDUCED APOPTOSIS ; PROTECTIVE ROLE ; RADIATION ; CELLS ; INDUCTION ; RESPONSES |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000250801100020 |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5865]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China 2.Inst Med Sci Gansu Province, Lanzhou 73000, Peoples R China 3.Gansu Agr Univ, Lanzhou 730070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yang,Zhang, Hong,Zhang, Luwei,et al. Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2007,575(1--3):142-148. |
| APA | Liu, Yang.,Zhang, Hong.,Zhang, Luwei.,Zhou, Qingming.,Wang, Xiaohu.,...&Zhao, Weiping.(2007).Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice.EUROPEAN JOURNAL OF PHARMACOLOGY,575(1--3),142-148. |
| MLA | Liu, Yang,et al."Antioxidant N-acetylcysteine attenuates the acute liver injury caused by X-ray in mice".EUROPEAN JOURNAL OF PHARMACOLOGY 575.1--3(2007):142-148. |
入库方式： OAI收割
来源：近代物理研究所
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