A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation
文献类型：期刊论文
| 作者 | Yang Jianshe; Jing Xigang; Wang Zhuanzi; Li Wenjian |
| 刊名 | CENTRAL EUROPEAN JOURNAL OF BIOLOGY
 |
| 出版日期 | 2006-09-01 |
| 卷号 | 1期号:3页码:451-462 |
| 关键词 | radiation sensitivity chromatid break cancer cell Calyculin A premature chromosome condensation |
| ISSN号 | 1895-104X |
| DOI | 10.2478/s11535-006-0028-0 |
| 英文摘要 | Three human malignancy cell lines were irradiated with Co-60 gamma-rays. Initial chromatid breaks were measured by using the chemically induced premature chromosome condensation technique. Survival curves of cells exposed to gamma rays was linear-quadratic while the efficiency of Calyculin A in inducing PCC of G(2) PCC was about five times more than G(1) PCC. A dose-dependent increase in radiation-induced chromatid/isochromatid breaks was observed in G(1) and G(2) phase PCC and a nearly positive linear correlation was found between cell survival and chromatin breaks. This study implies that low LET radiation-induced chromatid/isochromatid breaks can potentially be used to predict the radiosensitivity of tumor cells either in in vitro experimentation or in in vivo clinical radiotherapy. (c) Versita Warsaw and Springer-Verlab Berlin Heidelberg. All rights reserved. |
| WOS关键词 | INDUCED CHROMOSOME-ABERRATIONS ; HUMAN INTERPHASE CHROMOSOMES ; IN-SITU HYBRIDIZATION ; HUMAN FIBROBLASTS ; INTRINSIC RADIOSENSITIVITY ; ATAXIA-TELANGIECTASIA ; CHARGED-PARTICLES ; DAMAGE ; INDUCTION ; CARCINOMA |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000246983300010 |
| 出版者 | VERSITA |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/5971]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Yang Jianshe |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.NW Normal Univ, Life Sci Sch, Lanzhou 730070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang Jianshe,Jing Xigang,Wang Zhuanzi,et al. A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation[J]. CENTRAL EUROPEAN JOURNAL OF BIOLOGY,2006,1(3):451-462. |
| APA | Yang Jianshe,Jing Xigang,Wang Zhuanzi,&Li Wenjian.(2006).A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation.CENTRAL EUROPEAN JOURNAL OF BIOLOGY,1(3),451-462. |
| MLA | Yang Jianshe,et al."A correlation between radiation sensitivity and initial chromatid breaks in cancer cell lines revealed by Calyculin A-induced premature condensation".CENTRAL EUROPEAN JOURNAL OF BIOLOGY 1.3(2006):451-462. |
入库方式： OAI收割
来源：近代物理研究所
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