Simulations to design an online motion compensation system for scanned particle beams
文献类型：期刊论文
| 作者 | Groezinger, Sven Oliver; Rietzel, Eike; Li, Qiang; Bert, Christoph ; Haberer, Thomas; Kraft, Gerhard
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| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2006-07-21 |
| 卷号 | 51期号:14页码:3517-3531 |
| ISSN号 | 0031-9155 |
| DOI | 10.1088/0031-9155/51/14/016 |
| 英文摘要 | Respiration-induced target motion is a major problem in intensity-modulated radiation therapy. Beam segments are delivered serially to form the total dose distribution. In the presence of motion, the spatial relation between dose deposition from different segments will be lost. Usually, this results in over-and underdosage. Besides such interplay effects between target motion and dynamic beam delivery as known from photon therapy, changes in internal density have an impact on delivered dose for intensity-modulated charged particle therapy. In this study, we have analysed interplay effects between raster scanned carbon ion beams and target motion. Furthermore, the potential of an online motion strategy was assessed in several simulations. An extended version of the clinical treatment planning software was used to calculate dose distributions to moving targets with and without motion compensation. For motion compensation, each individual ion pencil beam tracked the planned target position in the lateral aswell as longitudinal direction. Target translations and rotations, including changes in internal density, were simulated. Target motion simulating breathing resulted in severe degradation of delivered dose distributions. For example, for motion amplitudes of +/- 15 mm, only 47% of the target volume received 80% of the planned dose. Unpredictability of resulting dose distributions was demonstrated by varying motion parameters. On the other hand, motion compensation allowed for dose distributions for moving targets comparable to those for static targets. Even limited compensation precision (standard deviation similar to 2 mm), introduced to simulate possible limitations of real-time target tracking, resulted in less than 3% loss in dose homogeneity. |
| WOS关键词 | ORGAN MOTION ; RESPIRATORY MOTION ; CONFORMAL RADIOTHERAPY ; TARGET VOLUME ; SET-UP ; TUMOR ; TRACKING ; THERAPY ; DELIVERY ; CANCER |
| WOS研究方向 | Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000238945700017 |
| 出版者 | IOP PUBLISHING LTD |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/6177]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Groezinger, Sven Oliver |
| 作者单位 | 1.GSI Darmstadt, D-64291 Darmstadt, Germany 2.Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02114 USA 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Groezinger, Sven Oliver,Rietzel, Eike,Li, Qiang,et al. Simulations to design an online motion compensation system for scanned particle beams[J]. PHYSICS IN MEDICINE AND BIOLOGY,2006,51(14):3517-3531. |
| APA | Groezinger, Sven Oliver,Rietzel, Eike,Li, Qiang,Bert, Christoph,Haberer, Thomas,&Kraft, Gerhard.(2006).Simulations to design an online motion compensation system for scanned particle beams.PHYSICS IN MEDICINE AND BIOLOGY,51(14),3517-3531. |
| MLA | Groezinger, Sven Oliver,et al."Simulations to design an online motion compensation system for scanned particle beams".PHYSICS IN MEDICINE AND BIOLOGY 51.14(2006):3517-3531. |
入库方式： OAI收割
来源：近代物理研究所
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