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Effect of p53 on lung carcinoma cells irradiated by carbon ions or X-rays

文献类型：期刊论文

作者Xie Yi1; Zhang Hong1; Hao Jifang1; Zhao Weiping1; Wu Zhenhua1; Qiu Rong1; Wang Xiaohu2
刊名NUCLEAR SCIENCE AND TECHNIQUES
出版日期2009-06-01
卷号20期号:3页码:146-151
关键词(12)C(6+) ion irradiation Expression of p53 Cellular cycle and apoptosis Survival of cells X-ray
ISSN号1001-8042
英文摘要The study is to investigate the feasibility and advantages of heavy ion beams on radiotherapy. The cellular cycle and apoptosis, cell reproductive death and p53 expression evaluated with flow cytometry, clonogenic survival assays and Western blot analysis were examined in lung carcinoma cells after exposure to 89.63 MeV/u carbon ion and 6 MV X-ray irradiations, respectively. The results showed that the number colonyforming assay of A549 was higher than that of H1299 cells in two radiation groups; A549 cellular cycle was arrested in G(2)/M in 12 It and the percentage of apoptosis ascended at each time point of carbon ion radiation with doses, the expression of p53 upregulated with doses exposed to X-ray or carbon ion. The cell number in G(2)/M of H1299 and apoptosis were increasing at all time points with doses in (12)C(6+) ion irradiation group. The results suggested that the effects of carbon ions or X rays irradiation on lung carcinoma cells were different, (12)C(6+) ion irradiation could have more effect on upregulating the expression of p53 than X-ray, and the upregulated expression of p53 might produce the cellular cycle G(2)/M arrested, apoptosis increasing; and p53 gene might affect the lung cancer cells radiosensitivity.
WOS关键词IN-VITRO ; CANCER CELLS ; WILD-TYPE ; RADIATION ; P21 ; RADIOSENSITIVITY ; SUPPRESSION ; INHIBITOR ; APOPTOSIS ; THERAPY
资助项目National Natural Science Foundation of China[10675151] ; National Natural Science Foundation of China[10835011] ; Key Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Key Scientific Technology Research Projects of Gansu Province[0801NKDA001] ; Lanzhou[07-2-07]
WOS研究方向Nuclear Science & Technology ; Physics
语种英语
WOS记录号WOS:000268943400004
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China ; Key Scientific Technology Research Projects of Gansu Province ; Lanzhou
公开日期2010-10-29
源URL[http://ir.imp.cas.cn/handle/113462/6305]  
专题近代物理研究所_近代物理研究所知识存储（2010之前）
通讯作者Zhang Hong
作者单位1.Chinese Acad Sci, Dept Med Radiat Biol, Inst Modern Phys, Lanzhou 730000, Peoples R China
2.Inst Med Sci Gansu Prov, Dept Radiotherapy, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Xie Yi,Zhang Hong,Hao Jifang,et al. Effect of p53 on lung carcinoma cells irradiated by carbon ions or X-rays[J]. NUCLEAR SCIENCE AND TECHNIQUES,2009,20(3):146-151.
APA Xie Yi.,Zhang Hong.,Hao Jifang.,Zhao Weiping.,Wu Zhenhua.,...&Wang Xiaohu.(2009).Effect of p53 on lung carcinoma cells irradiated by carbon ions or X-rays.NUCLEAR SCIENCE AND TECHNIQUES,20(3),146-151.
MLA Xie Yi,et al."Effect of p53 on lung carcinoma cells irradiated by carbon ions or X-rays".NUCLEAR SCIENCE AND TECHNIQUES 20.3(2009):146-151.

入库方式： OAI收割

来源：近代物理研究所

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