Potential role of DNA-dependent protein kinase in cellular resistance to ionizing radiation
文献类型：期刊论文
| 作者 | Li Ning1,2,3 ; Zhang Hong1,2; Wang Yanling1,2,3; Wang Xiaohu4; Hao Jifang1,2
|
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2009-04-01 |
| 卷号 | 20期号:2页码:87-92 |
| 关键词 | DNA-dependent protein kinase (DNA-PK) Cell cycle checkpoint Apoptosis Radiosensitivity |
| ISSN号 | 1001-8042 |
| 英文摘要 | In this paper, we study the ability of DNA-PK-deficient (M059J) and -proficient (M059K) cells to undergo the rate of cellular proliferation, cell cycle distribution and apoptosis after 10 Gy X-ray irradiation, and the role of DNA-PK in radiosensitivity. The results showed that M059J cells exhibited hyper-radiosensitivity compared with M059K cells. A strong G2 phase arrest was observed in M059J cells post irradiation. Significant accumulation in the G2 phase in M059J cells was accompanied by apoptosis at 12 h. Altogether, the data suggested that DNA-PK may have two roles in mammalian cells after DNA damage, a role in DNA DSB repair and a second role in DNA-damaged cells to traverse a G2 checkpoint, by which DNA-PK may affect cellular sensitivity to ionizing radiation. |
| WOS关键词 | DOUBLE-STRAND BREAKS ; CATALYTIC SUBUNIT ; MAMMALIAN-CELLS ; P53-DEPENDENT APOPTOSIS ; M059K CELLS ; REPAIR ; CYCLE ; PATHWAYS ; DEATH ; MICE |
| 资助项目 | National Natural Science Foundation of China[10675151] ; Chinese Academy of Sciences[0860260XBO] |
| WOS研究方向 | Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000266620000005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China ; Chinese Academy of Sciences |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/6309]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Zhang Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Gansu Tumor Hosp, Dept Radiotherapy, Lanzhou 730050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Ning,Zhang Hong,Wang Yanling,et al. Potential role of DNA-dependent protein kinase in cellular resistance to ionizing radiation[J]. NUCLEAR SCIENCE AND TECHNIQUES,2009,20(2):87-92. |
| APA | Li Ning,Zhang Hong,Wang Yanling,Wang Xiaohu,&Hao Jifang.(2009).Potential role of DNA-dependent protein kinase in cellular resistance to ionizing radiation.NUCLEAR SCIENCE AND TECHNIQUES,20(2),87-92. |
| MLA | Li Ning,et al."Potential role of DNA-dependent protein kinase in cellular resistance to ionizing radiation".NUCLEAR SCIENCE AND TECHNIQUES 20.2(2009):87-92. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。