Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions
文献类型：期刊论文
| 作者 | Liu Yang1 ; Zhang Hong1; Zhang Luwei2
|
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2008-02-20 |
| 卷号 | 19期号:1页码:17-21 |
| 关键词 | sex specificity oxidative stress C-12(6+) ion mouse lung |
| ISSN号 | 1001-8042 |
| 英文摘要 | The aim of this work is to identify if there is sex specificity on C-12(6+) ion-induced oxidative damage in mouse lung at different time points. Kun-Ming mice were divided into two groups, each composed of six males and six females: control group and irradiation group with a single acute dose of 4 Gy. Animals were sacrificed at 2, 4 and 12 h respectively, there lungs were removed immediately, and the oxidative stress-related biomarkers were measured by Diagnostic Reagent Kits. The results showed that the relative activities of superoxide dismutase (4 h), catalase (2 h) and Se-dependent glutathione peroxidase (12 h) have significant changes (P < 0.05) between male groups and female groups, suggesting that the lungs of male mice are more sensitive to counteracting the oxidative challenge. Moreover, higher levels of malondiadehyde and lower contents of glutathione were also found in males, indicating that oxidative stress induced by C-12(6+) ion is pronounced in the lungs of males. We thought that these sex-responded differences may be attributed to the influence of sex hormones. |
| WOS关键词 | X-RAY-IRRADIATION ; ENVIRONMENTAL-POLLUTANTS ; METHYLATION CHANGES ; IONIZING-RADIATION ; INDUCED APOPTOSIS ; PROTECTIVE ROLE ; OH RADICALS ; FEMALE MICE ; BRAIN ; MITOCHONDRIA |
| WOS研究方向 | Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000254968500004 |
| 出版者 | ELSEVIER SCIENCE BV |
| 公开日期 | 2010-10-29 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/6337]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Zhang Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China 2.Gansu Agr Univ, Lanzhou 730070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu Yang,Zhang Hong,Zhang Luwei. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions[J]. NUCLEAR SCIENCE AND TECHNIQUES,2008,19(1):17-21. |
| APA | Liu Yang,Zhang Hong,&Zhang Luwei.(2008).Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions.NUCLEAR SCIENCE AND TECHNIQUES,19(1),17-21. |
| MLA | Liu Yang,et al."Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions".NUCLEAR SCIENCE AND TECHNIQUES 19.1(2008):17-21. |
入库方式： OAI收割
来源：近代物理研究所
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