中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions

文献类型:期刊论文

作者Liu Yang1; Zhang Hong1; Zhang Luwei2
刊名NUCLEAR SCIENCE AND TECHNIQUES
出版日期2008-02-20
卷号19期号:1页码:17-21
关键词sex specificity oxidative stress C-12(6+) ion mouse lung
ISSN号1001-8042
英文摘要The aim of this work is to identify if there is sex specificity on C-12(6+) ion-induced oxidative damage in mouse lung at different time points. Kun-Ming mice were divided into two groups, each composed of six males and six females: control group and irradiation group with a single acute dose of 4 Gy. Animals were sacrificed at 2, 4 and 12 h respectively, there lungs were removed immediately, and the oxidative stress-related biomarkers were measured by Diagnostic Reagent Kits. The results showed that the relative activities of superoxide dismutase (4 h), catalase (2 h) and Se-dependent glutathione peroxidase (12 h) have significant changes (P < 0.05) between male groups and female groups, suggesting that the lungs of male mice are more sensitive to counteracting the oxidative challenge. Moreover, higher levels of malondiadehyde and lower contents of glutathione were also found in males, indicating that oxidative stress induced by C-12(6+) ion is pronounced in the lungs of males. We thought that these sex-responded differences may be attributed to the influence of sex hormones.
WOS关键词X-RAY-IRRADIATION ; ENVIRONMENTAL-POLLUTANTS ; METHYLATION CHANGES ; IONIZING-RADIATION ; INDUCED APOPTOSIS ; PROTECTIVE ROLE ; OH RADICALS ; FEMALE MICE ; BRAIN ; MITOCHONDRIA
WOS研究方向Nuclear Science & Technology ; Physics
语种英语
WOS记录号WOS:000254968500004
出版者ELSEVIER SCIENCE BV
公开日期2010-10-29
源URL[http://ir.imp.cas.cn/handle/113462/6337]  
专题近代物理研究所_近代物理研究所知识存储(2010之前)
通讯作者Zhang Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Med Phys, Lanzhou 730000, Peoples R China
2.Gansu Agr Univ, Lanzhou 730070, Peoples R China
推荐引用方式
GB/T 7714
Liu Yang,Zhang Hong,Zhang Luwei. Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions[J]. NUCLEAR SCIENCE AND TECHNIQUES,2008,19(1):17-21.
APA Liu Yang,Zhang Hong,&Zhang Luwei.(2008).Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions.NUCLEAR SCIENCE AND TECHNIQUES,19(1),17-21.
MLA Liu Yang,et al."Evaluation of sex specificity on oxidative stress induced in lungs of mice irradiated by C-12(6+) ions".NUCLEAR SCIENCE AND TECHNIQUES 19.1(2008):17-21.

入库方式: OAI收割

来源:近代物理研究所

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