Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1
文献类型：期刊论文
| 作者 | Hall, E. J.2; Zhou, G.3; Smilenov, L. B.2; Lieberman, H. B.2; Ludwig, T.1 |
| 刊名 | ADVANCES IN SPACE RESEARCH
 |
| 出版日期 | 2010-09-15 |
| 卷号 | 46期号:6页码:681-686 |
| 关键词 | Atm Rad9 Brca1 (56)Fe ions Heterozygosity Haploinsufficiency |
| ISSN号 | 0273-1177 |
| DOI | 10.1016/j.asr.2010.02.026 |
| 英文摘要 | Loss of function of DNA repair genes has been implicated in the development of many types of cancer. In the last several years, heterozygosity leading to haploinsufficiency for proteins involved in DNA repair was shown to play a role in genomic instability and carcinogenesis after DNA damage is induced, for example by ionizing radiation. Since the effect of heterozygosity for one gene is relatively small, we hypothesize that predisposition to cancer could be a result of the additive effect of heterozygosity for two or more genes critical to pathways that control DNA damage signaling, repair or apoptosis. We investigated the role of heterozygosity for Aim, Rad9 and Brad on cell oncogenic transformation and cell survival induced by 1 GeV/n (56)Fe ions. Our results show that cells heterozygous for both Aim and Rad9 or A tin and Brca1 have high survival rates and are more sensitive to transformation by high energy iron ions when compared with wild-type controls or cells haploinsufficient for only one of these proteins. Since mutations or polymorphisms for similar genes exist in a small percentage of the human population, we have identified a radiosensitive sub-population. This finding has several implications. First, the existence of a radiosensitive sub-population may distort the shape of the dose response relationship. Second, it would not be ethical to put exceptionally radiosensitive individuals into a setting where they may potentially be exposed to substantial doses of radiation. (C) 2010 COSPAR. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | BREAST-CANCER SUSCEPTIBILITY ; CELLULAR-RESPONSES ; DNA-DAMAGE ; X-RAY ; HAPLOINSUFFICIENCY ; RADIATION ; MICE ; GENE ; PREDISPOSITION ; APOPTOSIS |
| 资助项目 | DOE[DE-FG02-03ER63629] ; NASA[NAG9-1519] ; NASA[NNJ05H138G] ; NIH[GM0791 07] |
| WOS研究方向 | Astronomy & Astrophysics ; Geology ; Meteorology & Atmospheric Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000281296600001 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | DOE ; NASA ; NIH |
| 公开日期 | 2011-04-20 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/7787]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 通讯作者 | Smilenov, L. B. |
| 作者单位 | 1.Columbia Univ, Med Ctr, Inst Canc Genet, New York, NY 10032 USA 2.Columbia Univ, Med Ctr, Ctr Radiol Res, New York, NY 10032 USA 3.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Biol & Med, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hall, E. J.,Zhou, G.,Smilenov, L. B.,et al. Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1[J]. ADVANCES IN SPACE RESEARCH,2010,46(6):681-686. |
| APA | Hall, E. J.,Zhou, G.,Smilenov, L. B.,Lieberman, H. B.,&Ludwig, T..(2010).Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1.ADVANCES IN SPACE RESEARCH,46(6),681-686. |
| MLA | Hall, E. J.,et al."Radiosensitivity to high energy iron ions is influenced by heterozygosity for Atm, Rad9 and Brca1".ADVANCES IN SPACE RESEARCH 46.6(2010):681-686. |
入库方式： OAI收割
来源：近代物理研究所
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