Inhibiting Survivin Expression Increases The Radiosensitivity of Human Hepatoma HepG2 Cells to High-LET Radiation
文献类型：期刊论文
| 作者 | Jin Xiao-Dong1 ; Liu Xin-Guo1,2; Dai Zhong-Ying1,2; Hao Ji-Fang1; Tao Jia-Jun1,2; Li Ping1,2; Wu Qing-Feng1,2; Li Qiang1
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| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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| 出版日期 | 2010 |
| 卷号 | 37期号:1页码:79-84 |
| 关键词 | Survivin High-let Radiation Sirna Apoptosis |
| ISSN号 | 1000-3282 |
| DOI | 10.3724/SP.J.1206.2009.00403 |
| 英文摘要 | The influence of survivin expression on the radiosensitivity of tumor cells to high linear energy transfer (LET) radiation is investigated. Survivin-specific short-interfering RNA (siRNA) oligonucleotides were synthesized based on the survivin sequence provided by GenBank. Human hepatoma HepG2 cells were transfected with survivin-specific siRNA to inhibit its expressions. It was found that the transfection with surviving-specific siRNA increased the levels of G2/M arrest and the apoptotic rates induced by radiation in HepG2 cells. After exposure to high-LET carbon ions, a reduced clonogenic survival effect was observed in the cells treated with siRNA. These results show that survivin plays a key role in mediating the radioresistance of cells to high-LET radiation. |
| WOS关键词 | Therapeutic Target ; Cancer Cells ; Radiotherapy |
| 资助项目 | Hi-Tech Research and Development Program of China[2006AA02Z499] ; Key Project of National Natural Science Foundation of China[10835011] ; The National Natural Science Foundation of China[10905080] ; Western Talents Program of Chinese Academy of Science[0962030XBO] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000273981400012 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 资助机构 | Hi-Tech Research and Development Program of China ; Key Project of National Natural Science Foundation of China ; The National Natural Science Foundation of China ; Western Talents Program of Chinese Academy of Science |
| 公开日期 | 2011-04-20 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/7949]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin Xiao-Dong,Liu Xin-Guo,Dai Zhong-Ying,et al. Inhibiting Survivin Expression Increases The Radiosensitivity of Human Hepatoma HepG2 Cells to High-LET Radiation[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2010,37(1):79-84. |
| APA | Jin Xiao-Dong.,Liu Xin-Guo.,Dai Zhong-Ying.,Hao Ji-Fang.,Tao Jia-Jun.,...&Li Qiang.(2010).Inhibiting Survivin Expression Increases The Radiosensitivity of Human Hepatoma HepG2 Cells to High-LET Radiation.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,37(1),79-84. |
| MLA | Jin Xiao-Dong,et al."Inhibiting Survivin Expression Increases The Radiosensitivity of Human Hepatoma HepG2 Cells to High-LET Radiation".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37.1(2010):79-84. |
入库方式： OAI收割
来源：近代物理研究所
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