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Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus

文献类型：期刊论文

作者Wang Xue-hong3; Liu Yu3; Shang Ruo-feng3; Liang Jian-ping2,3; Pu Xiu-ying1,3; Wang Zuo-xin1,3; Hua Lan-ying3
刊名AGRICULTURAL SCIENCES IN CHINA
出版日期2009-06-20
卷号8期号:6页码:730-739
关键词porcine respiratory and reproductive syndrome virus (PRRSV) porcine respiratory and reproductive syndrome (PRRS) Hypericum perforatum extract (HPE) piglet
ISSN号1671-2927
DOI10.1016/S1671-2927(08)60272-2
英文摘要To study the influence of Hypericum perforatum extract (HPE) on piglets infected with porcine respiratory and reproductive syndrome virus (PRRSV), enzyme-labeled immunosorbent assay (ELISA) and cytopathic effect (CPE) were used to determine in vitro whether HPE could induce swine pulmonary alveolar macrophages (PAMs) to secrete IFN-gamma, and whether PRRSV titers in PAMs were affected by the levels of HPE-induced IFN-gamma. HPE (200 mg kg(-1)) was administrated by oral gavage to piglets infected with the PRRSV in vivo to observe whether HPE affected the viremia, lung viral titers, and weight gain of piglets infected with PRRSV. The results showed that HPE was capable of inducing PAMs to produce IFN-gamma in a dose dependent manner and HPE pretreatment was capable of significantly reducing PRRSV viral titers in PAMs (P<0.01). Administration of HPE to the PRRSV-infected animals significantly (P<0.05) reduced viremia over time as compared with the PRRSV-infected animals. But there was not significant decrease in lung viral titers at day 21 post-infection between the HPE-treated animals and the PRRSV-infected control piglets. There were no significant differences in weight gain over time among the HPE-treatment animals, the normal control, and the HPE control animals. The PRRSV-infected animals caused significant (P<0.01) growth retardation as compared with the HPE controls and the normal piglets. It suggested that HPE might be an effective novel therapeutic approach to diminish the PRRSV-induced disease in swine.
WOS关键词HUMAN-IMMUNODEFICIENCY-VIRUS ; ISOLATE ATCC VR-2332 ; INTERFERON-GAMMA ; ANTHRAQUINONE DERIVATIVES ; ALVEOLAR MACROPHAGES ; ANTIVIRAL ACTIVITY ; VIRUCIDAL ACTIVITY ; SWINE INFERTILITY ; GNOTOBIOTIC PIGS ; IMMUNE-RESPONSE
资助项目State Level Research Institutes for Public Welfare, China[BRF070402] ; Chinese Academy of Sciences[Renjiaozi [2008] 287]
WOS研究方向Agriculture
语种英语
WOS记录号WOS:000278076000014
出版者ELSEVIER SCI LTD
资助机构State Level Research Institutes for Public Welfare, China ; Chinese Academy of Sciences
公开日期2011-04-20
源URL[http://ir.imp.cas.cn/handle/113462/7951]  
专题近代物理研究所_近代物理研究所知识存储（2010之前）
近代物理研究所_重离子辐照药物研发中心
通讯作者Liang Jian-ping
作者单位1.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
3.Chinese Acad Agr Sci, Lanzhou Inst Anim & Vet Pharmaceut Sci, Lanzhou 730050, Peoples R China
推荐引用方式
GB/T 7714		 Wang Xue-hong,Liu Yu,Shang Ruo-feng,et al. Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus[J]. AGRICULTURAL SCIENCES IN CHINA,2009,8(6):730-739.
APA Wang Xue-hong.,Liu Yu.,Shang Ruo-feng.,Liang Jian-ping.,Pu Xiu-ying.,...&Hua Lan-ying.(2009).Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus.AGRICULTURAL SCIENCES IN CHINA,8(6),730-739.
MLA Wang Xue-hong,et al."Influence of Hypericum perforatum Extract on Piglet Infected with Porcine Respiratory and Reproductive Syndrome Virus".AGRICULTURAL SCIENCES IN CHINA 8.6(2009):730-739.

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来源：近代物理研究所

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