Effects of Ionizing Radiation on Three-Dimensional Human Vessel Models: Differential Effects According to Radiation Quality and Cellular Development
文献类型：期刊论文
| 作者 | Sharma, Preety; Grabham, Peter; Hu, Burong1 ; Geard, Charles2
|
| 刊名 | RADIATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 175期号:1页码:21-28 |
| ISSN号 | 0033-7587 |
| DOI | 10.1667/RR2289.1 |
| 英文摘要 | Little is known about the effects of space radiation on the human body. There are a number of potential chronic and acute effects, and one major target for noncarcinogenic effects is the human vasculature. Cellular stress, inflammatory response, and other radiation effects on endothelial cells may affect vascular function. This study was aimed at understanding the effects of space ionizing radiation on the formation and maintenance of capillary-like blood vessels. We used a 3D human vessel model created with human endothelial cells in a gel matrix to assess the effects of low-LET protons and high-LET iron ions. Iron ions were more damaging and caused significant reduction in the length of intact vessels in both developing and mature vessels at a dose of 80 cGy. Protons had no effect on mature vessels up to a dose of 3.2 Gy but did inhibit vessel formation at 80 cGy. Comparison with gamma radiation showed that photons had even less effect, although, as with protons, developing vessels were more sensitive. Apoptosis assays showed that inhibition of vessel development or deterioration of mature vessels was not due to cell death by apoptosis even in the case of iron ions. These are the first data to show the effects of radiation with varying linear energy transfer on a human vessel model. (C) 2011 In Radiation Research Society |
| WOS关键词 | IN-VITRO ; COLLAGEN MATRICES ; SPACE EXPLORATION ; TUBE FORMATION ; ANGIOGENESIS ; MORPHOGENESIS ; MECHANISM ; DISEASE ; CANCER ; RAYS |
| 资助项目 | NASA[NNJ05H137G] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000285858800003 |
| 出版者 | RADIATION RESEARCH SOC |
| 资助机构 | NASA |
| 公开日期 | 2011-05-16 |
| 源URL | [http://ir.imp.cas.cn/handle/113462/8197]  |
| 专题 | 近代物理研究所_近代物理研究所知识存储（2010之前） 近代物理研究所_空间辐射生物研究室 |
| 通讯作者 | Geard, Charles |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 73000, Peoples R China 2.Columbia Univ, Coll Phys & Surg, Dept Pathol, Ctr Radiol Res, New York, NY 10032 USA |
| 推荐引用方式 GB/T 7714 | Sharma, Preety,Grabham, Peter,Hu, Burong,et al. Effects of Ionizing Radiation on Three-Dimensional Human Vessel Models: Differential Effects According to Radiation Quality and Cellular Development[J]. RADIATION RESEARCH,2011,175(1):21-28. |
| APA | Sharma, Preety,Grabham, Peter,Hu, Burong,&Geard, Charles.(2011).Effects of Ionizing Radiation on Three-Dimensional Human Vessel Models: Differential Effects According to Radiation Quality and Cellular Development.RADIATION RESEARCH,175(1),21-28. |
| MLA | Sharma, Preety,et al."Effects of Ionizing Radiation on Three-Dimensional Human Vessel Models: Differential Effects According to Radiation Quality and Cellular Development".RADIATION RESEARCH 175.1(2011):21-28. |
入库方式： OAI收割
来源：近代物理研究所
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