The excitation function of the ~(238)U(~9Be, 5n) reaction was obtained for the first time. By using a stack of uranium targets, 20 experimental data were obtained by the on-line irradiation without changing beam energy. Taking the advantage of the long lifetime and alpha decay mode of the residue nucleus ~(242)Cm, the off-line measurement of the alpha radioactive was performed to obtain its yields. The maximum cross section is about 1 mb. The curve's shape and the maximum's position agree with the present model. The value of the cross section will help us to develop the ralated models, and push the nuclear studies in the transuranium region.