The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations
文献类型：期刊论文
| 作者 | Dai, ZY ; Zhao, T; Chen, WQ (reprint author), Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Peoples R China.; Li, Q; Chen, WQ; Liu, Y; Liu, X; Jin, XD; He, PB; Zheng, XG
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| 刊名 | PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
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| 出版日期 | 2015 |
| 卷号 | 31页码:210-218 |
| 关键词 | Platinum-containing Molecules Fast Atomic Ions Mammalian-cells Cancer-therapy Radiosensitization Irradiation Radiotherapy Size Photon |
| ISSN号 | 1120-1797 |
| DOI | 10.1016/j.ejmp.2015.01.006 |
| 英文摘要 | We examined the dependence of hydroxyl radical production on the concentration of 15 nm citrate-capped AuNPs and dose using coumarin-3-carboxylic acid in phosphate buffered saline (PBS), and investigated the radiosensitisation of different concentration AuNPs on human cervix carcinoma HeLa cells through clonogenic survival assay for X-rays and carbon ions. The enhancement factor of AuNPs for hydroxyl radical production reached a maximum 3.66 for X-rays at the concentration of 0.1 mg/mL while the maximum was 5.52 for carbon ions in presence of 1.0 mu g/mL AuNPs in PBS. At 50% survival level, the sensitizer enhancement ratios of X-rays and carbon ions varied from 1.14 to 2.88 and from 1.27 to 1.44, respectively, when cells were co-cultured with 1.5-15.0 mu g/mL AuNPs. Our data indicate AuNPs showed radiosensitisation in terms of hydroxyl radical production and cell killing for low- and high-LET radiations. The concentration of AuNPs in PBS and cells played an important role in radiosensitizing effect. Based on the fact-the AuNPs in PBS could improve the production of hydroxyl radical and no accumulation of cells in the G(2)/M phase was observed, we deduce that the increment of hydroxyl radical production with AuNPs provided a mechanism for radiosensitisation. (C) 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved. |
| URL标识 | 查看原文 |
| WOS关键词 | PLATINUM-CONTAINING MOLECULES ; FAST ATOMIC IONS ; MAMMALIAN-CELLS ; CANCER-THERAPY ; RADIOSENSITIZATION ; RADIOTHERAPY ; IRRADIATION ; SIZE ; SIMULATION ; PROTONS |
| 资助项目 | Gansu Provincial Funds for Distinguished Young Scientists (Gansu Provincial Sci. & Tech. Department)[1111RJDA010] |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000351732600004 |
| 出版者 | ELSEVIER SCI LTD |
| 资助机构 | National Natural Science Foundation of China [11075191, 11205217, U1232207] ; National Natural Science Foundation of China [11075191, 11205217, U1232207] |
| 源URL | [http://ir.impcas.ac.cn/handle/113462/18573]  |
| 专题 | 近代物理研究所_医学物理研究室 近代物理研究所_生物物理研究室 |
| 通讯作者 | Chen, WQ (reprint author), Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Peoples R China. |
| 作者单位 | 中国科学院近代物理研究所 |
| 推荐引用方式 GB/T 7714 | Dai, ZY,Zhao, T,Chen, WQ ,et al. The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations[J]. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,2015,31:210-218. |
| APA | Dai, ZY.,Zhao, T.,Chen, WQ .,Li, Q.,Chen, WQ.,...&Ye, F.(2015).The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations.PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS,31,210-218. |
| MLA | Dai, ZY,et al."The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations".PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 31(2015):210-218. |
入库方式： OAI收割
来源：近代物理研究所
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