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Respiratory motion management using audio-visual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery

文献类型：期刊论文

作者Ma, YY2; Shen, GS2; Fu, TY2; Zhao, T2; Dai, ZY2; Liu, XG2; He, PB2; Li, Q2; Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.; Yan, YL2
刊名MEDICAL PHYSICS
出版日期2014
卷号41页码:111708
关键词External Marker Tracking Inspiration Breath-hold Lung-tumor Motion Cancer Radiotherapy Moving Targets Therapy Irradiation System Model Compensation
ISSN号0094-2405
DOI10.1118/1.4897391
英文摘要Purpose: To efficiently deliver respiratory-gated radiation during synchrotron-based pulsed heavy-ion radiotherapy, a novel respiratory guidance method combining a personalized audio-visual biofeedback (BFB) system, breath hold (BH), and synchrotron-based gating was designed to help patients synchronize their respiratory patterns with synchrotron pulses and to overcome typical limitations such as low efficiency, residual motion, and discomfort. Methods: In-house software was developed to acquire body surface marker positions and display BFB, gating signals, and real-time beam profiles on a LED screen. Patients were prompted to perform short BHs or short deep breath holds (SDBH) with the aid of BFB following a personalized standard BH/SDBH (stBH/stSDBH) guiding curve or their own representative BH/SDBH (reBH/reSDBH) guiding curve. A practical simulation was performed for a group of 15 volunteers to evaluate the feasibility and effectiveness of this method. Effective dose rates (EDRs), mean absolute errors between the guiding curves and the measured curves, and mean absolute deviations of the measured curves were obtained within 10%-50% duty cycles (DCs) that were synchronized with the synchrotron's flat-top phase. Results: All maneuvers for an individual volunteer took approximately half an hour, and no one experienced discomfort during the maneuvers. Using the respiratory guidance methods, the magnitude of residual motion was almost ten times less than during nongated irradiation, and increases in the average effective dose rate by factors of 2.39-4.65, 2.39-4.59, 1.73-3.50, and 1.73-3.55 for the stBH, reBH, stSDBH, and reSDBH guiding maneuvers, respectively, were observed in contrast with conventional free breathing-based gated irradiation, depending on the respiratory-gated duty cycle settings. Conclusions: The proposed respiratory guidance method with personalized BFB was confirmed to be feasible in a group of volunteers. Increased effective dose rate and improved overall treatment precision were observed compared to conventional free breathing-based, respiratory-gated irradiation. Because breathing guidance curves could be established based on the respective average respiratory period and amplitude for each patient, it may be easier for patients to cooperate using this technique. (C) 2014 American Association of Physicists in Medicine.
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WOS关键词EXTERNAL MARKER TRACKING ; INSPIRATION BREATH-HOLD ; LUNG-TUMOR MOTION ; CANCER RADIOTHERAPY ; MOVING TARGETS ; THERAPY ; IRRADIATION ; SYSTEM ; MODEL ; COMPENSATION
资助项目Gansu Provincial Funds for Distinguished Young Scientists[1111RJDA010]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000344999800010
出版者AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS
资助机构Around five top priorities program of "One-Three-Five" Strategic Planning of Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences ; Around five top priorities program of "One-Three-Five" Strategic Planning of Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences ; National Science & Technology Major Project of China [2011ZX05011] ; National Science & Technology Major Project of China [2011ZX05011]
源URL[http://ir.impcas.ac.cn/handle/113462/18576]  
专题近代物理研究所_医学物理研究室
近代物理研究所_生物物理研究室
通讯作者Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.
作者单位1.Univ Chinese Acad Sci, Beijing Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou
2.Chinese Acad Sci, Inst Modern Phys, Lanzhou
3.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 2638555, Japan
推荐引用方式
GB/T 7714		 Ma, YY,Shen, GS,Fu, TY,et al. Respiratory motion management using audio-visual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery[J]. MEDICAL PHYSICS,2014,41:111708.
APA Ma, YY.,Shen, GS.,Fu, TY.,Zhao, T.,Dai, ZY.,...&Huang, QY.(2014).Respiratory motion management using audio-visual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery.MEDICAL PHYSICS,41,111708.
MLA Ma, YY,et al."Respiratory motion management using audio-visual biofeedback for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery".MEDICAL PHYSICS 41(2014):111708.

入库方式： OAI收割

来源：近代物理研究所

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