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Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells

文献类型：期刊论文

作者Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China.; Li, Q9; Furusawa, Y9; Liu, XX9; Ye, F9; Liu, Y9; Jin, XD9; Wu, QF9; Li, FF9; Zheng, XG9
刊名CANCER SCIENCE
出版日期2014
卷号105页码:770-778
关键词Malignant Glioma-cells Heavy-ion Irradiation Prostate-cancer Cells Dna-damage Response High-let Radiation Targeting Autophagy Sh-sy5y Cells A549 Cells Beclin 1 Apoptosis
ISSN号1347-9032
DOI10.1111/cas.12422
英文摘要Heavy-ion radiotherapy has a potential advantage over conventional radiotherapy due to improved dose distribution and a higher biological effectiveness in cancer therapy. However, there is a little information currently available on the cellular and molecular basis for heavy-ion irradiation-induced cell death. Autophagy, as a novel important target to improve anticancer therapy, has recently attracted considerable attention. In this study, the effect of autophagy induced by high linear energy transfer (LET) carbon ions was examined in various tumor cell lines. To our knowledge, our study is the first to reveal that high-LET carbon ions could induce autophagy in various tumor cells effectively, and the autophagic level in the irradiated cells increased in a dose-and LET-dependent manner. The ability of carbon ions to inhibit the activation of the PI3K/Akt pathway rose with increasing their LET. Moreover, modulation of autophagy in tumor cells could modify their sensitivity to high-LET radiation, and inhibiting autophagy accelerated apoptotic cell death, resulting in an increase in radiosensitivity. Our data imply that targeting autophagy might enhance the effectiveness of heavy-ion radiotherapy.
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WOS关键词MALIGNANT GLIOMA-CELLS ; HEAVY-ION IRRADIATION ; PROSTATE-CANCER CELLS ; DNA-DAMAGE RESPONSE ; HIGH-LET RADIATION ; TARGETING AUTOPHAGY ; SH-SY5Y CELLS ; A549 CELLS ; BECLIN 1 ; APOPTOSIS
资助项目Gansu Provincial Funds for Distinguished Young Scientists[1111RJDA010]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000340602800004
出版者WILEY-BLACKWELL
资助机构Research Project with Heavy-ions at NIRS-HIMAC [13J372] ; Research Project with Heavy-ions at NIRS-HIMAC [13J372] ; National Basic Research Program of China (973 Program) [2010CB834203] ; National Basic Research Program of China (973 Program) [2010CB834203] ; Key Project of National Natural Science Foundation of China [U1232207] ; Key Project of National Natural Science Foundation of China [U1232207] ; National Natural Science Foundation of China [11305223, 11075191, 11205217] ; National Natural Science Foundation of China [11305223, 11075191, 11205217] ; Gansu Provincial Funds for Distinguished Young Scientists [1111RJDA010] ; Gansu Provincial Funds for Distinguished Young Scientists [1111RJDA010]
源URL[http://ir.impcas.ac.cn/handle/113462/18578]  
专题近代物理研究所_医学物理研究室
近代物理研究所_生物物理研究室
通讯作者Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China.
作者单位1.Tang, Bo
2.Qing, Hong] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
3.Deng, Yulin
4.Ma, Hong
5.Dong, Yiming
6.[Wang, Xiao] China Inst Atom Energy, Beijing 102413, Peoples R China
7.[Li, Qiang] Lanzhou Inst Modern Phys, Lanzhou 730000, Peoples R China
8.[Gao, Qian] Gen Hosp Peoples Liberat Army Hosp 301, Beijing 100853, Peoples R China
9.[Ran, Yuanyuan
10.Wang, Ran
推荐引用方式
GB/T 7714		 Li, Q ,Li, Q,Furusawa, Y,et al. Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells[J]. CANCER SCIENCE,2014,105:770-778.
APA Li, Q .,Li, Q.,Furusawa, Y.,Liu, XX.,Ye, F.,...&Dai, ZY.(2014).Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells.CANCER SCIENCE,105,770-778.
MLA Li, Q ,et al."Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells".CANCER SCIENCE 105(2014):770-778.

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来源：近代物理研究所

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