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Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice

文献类型：期刊论文

作者Wang, X5; Li, Q5; Ma, H5; Deng, YL5; Qing, H5; Qing, H (reprint author), Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China.; Ran, YY5; Wang, R5; Gao, Q5; Jia, QT5
刊名JOURNAL OF RADIATION RESEARCH
出版日期2014
卷号55页码:699-706
关键词Gamma-radiation Croton-urucurana Leaf Extract Lipid-peroxidation Human-lymphocytes Peripheral-blood Protective Role In-vitro Damage Rats
ISSN号0449-3060
DOI10.1093/jrr/rru013
英文摘要Dragon's blood (DB) possesses great medicinal values due to the presence of several phenolic compounds. This study was designed to investigate the effects of DB and its extracts (DBEs) on oxidative stress in mice exposed to whole body Co-60-gamma irradiation (4 Gy). DB and DBEs were intragastrically administered to mice for 5 d prior to radiation. The antioxidant activities, including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels in liver and spleen were measured using kits. Furthermore, DB and DBE effects were determined by organ indices and histology of liver and spleen. Our results indicated that the DB and DBE-treated groups showed a significant decrease (P < 0.05) in levels of MDA in liver and spleen compared with the irradiation-only group. Moreover, the activity of SOD, CAT and the level of GSH in liver and spleen tissue were enhanced significantly (P < 0.05) in the DB and DBE groups. DB and DBE also had a significant effect on the recovery of thymus indices. The histological observations of groups having treatment with DB and DBE indicated significant reduction in the radiation-induced damage to the liver and spleen, together with improvement in the morphology of the liver and spleen. These results suggest that DB and DBE treatment prevents radiation-induced oxidative stress injury and restores antioxidant status and histopathological changes in the liver and spleen, but there is need for further study to explore the precise molecular mechanism and strategy for optimal practical application of DB and DBE.
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WOS关键词GAMMA-RADIATION ; CROTON-URUCURANA ; LEAF EXTRACT ; LIPID-PEROXIDATION ; HUMAN-LYMPHOCYTES ; PERIPHERAL-BLOOD ; PROTECTIVE ROLE ; IN-VITRO ; DAMAGE ; RATS
资助项目Natural Science Foundation of China[81171206]
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000339920200010
出版者OXFORD UNIV PRESS
资助机构National Basic Research Program of China (973 Program) [2010CB834203] ; National Basic Research Program of China (973 Program) [2010CB834203] ; Key Project of National Natural Science Foundation of China [U1232207] ; Key Project of National Natural Science Foundation of China [U1232207] ; National Natural Science Foundation of China [10905080, 11075191, 11205217] ; National Natural Science Foundation of China [10905080, 11075191, 11205217] ; Western Talents Program of the Chinese Academy of Sciences [O962030XBO] ; Western Talents Program of the Chinese Academy of Sciences [O962030XBO] ; Gansu Provincial Funds for Distinguished Young Scientists [1111RJDA010] ; Gansu Provincial Funds for Distinguished Young Scientists [1111RJDA010]
源URL[http://ir.impcas.ac.cn/handle/113462/18579]  
专题近代物理研究所_医学物理研究室
近代物理研究所_生物物理研究室
通讯作者Qing, H (reprint author), Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China.
作者单位1.Tang, Bo
2.Hasan, Murtaza
3.Lin, Fankai
4.Wang, Ran
5.[Ran, Yuanyuan
6.Xia, Yu
7.Jia, Qiutian
8.[Li, Qiang] Lanzhou Inst Modern Phys, Lanzhou 730000, Peoples R China
9.[Wang, Xiao] China Inst Atom Energy, Beijing 102413, Peoples R China
10.Qing, Hong] Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714		 Wang, X,Li, Q,Ma, H,et al. Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice[J]. JOURNAL OF RADIATION RESEARCH,2014,55:699-706.
APA Wang, X.,Li, Q.,Ma, H.,Deng, YL.,Qing, H.,...&Dong, YM.(2014).Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice.JOURNAL OF RADIATION RESEARCH,55,699-706.
MLA Wang, X,et al."Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice".JOURNAL OF RADIATION RESEARCH 55(2014):699-706.

入库方式： OAI收割

来源：近代物理研究所

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