Non-randomized mtDNA damage after ionizing radiation via charge transport
文献类型：期刊论文
| 作者 | Wang, ZH12; Zhang, H12 ; Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.; Zhou, X12; Liu, XG12; Zhang, X12; Zhou, R12; He, Y12; Li, Q12
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2012 |
| 卷号 | 2页码:780 |
| 关键词 | Mitochondrial-dna Repair Vertebrates Oxidation Evolution Cells |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep00780 |
| 英文摘要 | Although it is well known that there are mutation hot spots in mtDNA, whether there are damage hot spots remain elusive. In this study, the regional DNA damage of mitochondrial genome after ionizing radiation was determined by real-time quantitative PCR. The mtDNA damage level was found to be dose-dependent and regional unequal. The control region was the most susceptible region to oxidative damage. GGG, as an typical hole trap during charge transport, was found to be disproportionally enriched in the control region. A total of 107 vertebrate mitochondrial genomes were then analyzed to testify whether the GGG enrichment in control region was evolutionary conserved. Surprisingly, the triple G enrichment can be observed in most of the homeothermal animals, while the majority of heterothermic animals showed no triple G enrichment. These results indicated that the triple G enrichment in control region was related to the mitochondrial metabolism during evolution. |
| URL标识 | 查看原文 |
| WOS关键词 | MITOCHONDRIAL-DNA ; REPAIR ; VERTEBRATES ; OXIDATION ; EVOLUTION ; CELLS |
| 资助项目 | Western Talent Program of Chinese Academy of Sciences[0760160XBO] ; Western Talent Program of Chinese Academy of Sciences[0860260XBO] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000310451100001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.impcas.ac.cn/handle/113462/18584]  |
| 专题 | 近代物理研究所_医学物理研究室 近代物理研究所_生物物理研究室 |
| 通讯作者 | Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China. |
| 作者单位 | 1.Liu Xin-Guo 2.Ye Fei 3.Dai Zhong-Ying] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 4.[He Peng-Bo 5.Li Qiang 6.Liu Xin-Guo 7.Ye Fei 8.Dai Zhong-Ying] Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 9.[He Peng-Bo 10.Ye Fei |
| 推荐引用方式 GB/T 7714 | Wang, ZH,Zhang, H,Zhang, H ,et al. Non-randomized mtDNA damage after ionizing radiation via charge transport[J]. SCIENTIFIC REPORTS,2012,2:780. |
| APA | Wang, ZH.,Zhang, H.,Zhang, H .,Zhou, X.,Liu, XG.,...&Li, Q.(2012).Non-randomized mtDNA damage after ionizing radiation via charge transport.SCIENTIFIC REPORTS,2,780. |
| MLA | Wang, ZH,et al."Non-randomized mtDNA damage after ionizing radiation via charge transport".SCIENTIFIC REPORTS 2(2012):780. |
入库方式： OAI收割
来源：近代物理研究所
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