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miR-503-3p suppresses cell viability and promotes cell apoptosis in cancer cells

文献类型：期刊论文

作者Hu, Burong2; Ren, Zhenxin2; Wang, Jufang2; Li, Xiaoman1,2; Pan, Dong1,2; Du, Yarong2; Chen, Yaxiong2; Xue, Gang2
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
出版日期2016
卷号9页码:10943-10954
关键词miR-503-3p cell apoptosis RNA-sequencing 786-O p21
ISSN号1936-2625
英文摘要Studies have shown that microRNAs (miRNAs) can promote or suppress tumor growth and therefore act as targets for cancer therapy. Hsa-miR-503-5p, a mature miRNA derived from 5' ends of pre-miR-503, has been proved to regulate cell proliferation, transformation, migration and invasion. However, the biological function of miR-503-3p derived from 3' ends of pre-miR-503 has never been reported. In current study, we found that miR-503-3p inhibits tumor cell viability and induces cell apoptosis. To better understand the molecular mechanism underlying the miR-503-3p participating in this process, PCR array and RNA-sequencing (RNA-seq) were performed and some differential expression genes were discovered between NC and miR-503-3p treated groups. Biological interaction network showed that p21 and CDK4 are the most important proteins involving miR-503-3p signal pathway. Dual-luciferase assay results shown miR-503-3p directly regulates the expression of p21 by targeting 3'-UTR of its mRNA. These results shed light on the potential roles of miR-503-3p, indicating that it may act as an anti-oncogene factor to inhibit tumor cell viability.
WOS关键词LUNG-CANCER ; MICRORNA DEREGULATION ; DOWN-REGULATION ; BREAST-CANCER ; GLIOMA-CELLS ; C-JUN ; PROLIFERATION ; INVASION ; EXPRESSION ; PATHWAY
资助项目National Science Foundation of China[31170803] ; National Science Foundation of China[U1432121] ; Major Project Specialized for Infectious Diseases of the Chinese Health and Family Planning Commission[2014ZX10004002] ; Natural Science Foundation of Gansu Province[1308RJZA122]
WOS研究方向Oncology ; Pathology
语种英语
WOS记录号WOS:000392059400009
出版者E-CENTURY PUBLISHING CORP
资助机构National Science Foundation of China ; Major Project Specialized for Infectious Diseases of the Chinese Health and Family Planning Commission ; Natural Science Foundation of Gansu Province
源URL[http://119.78.100.186/handle/113462/44174]  
专题近代物理研究所_空间辐射生物研究室
通讯作者Hu, Burong; Ren, Zhenxin
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Lon Radiat Biol & Med, Gansu Key Lab Space Radiobiol, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Burong,Ren, Zhenxin,Wang, Jufang,et al. miR-503-3p suppresses cell viability and promotes cell apoptosis in cancer cells[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2016,9:10943-10954.
APA Hu, Burong.,Ren, Zhenxin.,Wang, Jufang.,Li, Xiaoman.,Pan, Dong.,...&Xue, Gang.(2016).miR-503-3p suppresses cell viability and promotes cell apoptosis in cancer cells.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,9,10943-10954.
MLA Hu, Burong,et al."miR-503-3p suppresses cell viability and promotes cell apoptosis in cancer cells".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 9(2016):10943-10954.

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来源：近代物理研究所

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