Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway
文献类型：期刊论文
| 作者 | Hu, Burong2,3 ; Gao, Kun1; Li, Ya1; Chen, Yaxiong2,3; Pan, Dong2,3; Sun, Meng1
|
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017-05-16 |
| 卷号 | 8页码:32807-32820 |
| 关键词 | coroglaucigenin Calotropis gigantea human lung cancer radiosensitivity Nrf2/ROS |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.16454 |
| 英文摘要 | Seven cardenolides isolated from the ethanol extract of the stems of Calotropis gigantea were evaluated in vitro against human cancer cells and the structure-activity relationships were discussed. The results demonstrated that a compound, named CGN (coroglaucigenin), had better anti-proliferative activity with the IC50 value less than 6 mu M among these compounds. Further, we found that CGN displayed much lower cytotoxicity to normal lung epithelial cells (BEAS-2B) than cancer cells (A549). Especially, our results demonstrated that treatment with CGN (1 mu M) combined with X-ray irradiation induced higher radiosensitivity in human lung cancer cells (A549, NCI-H460, NCI-H446) but not in BEAS-2B. The expression levels of nuclear transcription factor Nrf2 and Nrf2-driven antioxidant molecule NQO-1 reduced in A549 cells after combined treatment compared to the radiation only. However, CGN had no toxicity and the levels of antioxidant molecules expression were higher in BEAS-2B cells when given the similar treatment as A549 cells. These results suggest that CGN is a very promising potential sensitizer for cancer radiotherapy, which not only inhibits the proliferation of cancer cells but also enhances the radiosensitivity of cancer cells through suppressing the expression of antioxidant molecules while there is no influence for normal cells. |
| WOS关键词 | STRAND BREAK REPAIR ; CARDENOLIDE GLYCOSIDES ; GOMPHOCARPUS-SINAICUS ; PERGULARIA-TOMENTOSA ; PEROXIREDOXIN-II ; RADIATION ; IRRADIATION ; EPIGENETICS ; DEATH |
| 资助项目 | National Natural Science Foundation of China[31270396] ; National Natural Science Foundation of China[U1432121] ; Gansu Key Technologies R D Program[143NKDA028] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000401767700035 |
| 出版者 | IMPACT JOURNALS LLC |
| 资助机构 | National Natural Science Foundation of China ; Gansu Key Technologies R D Program |
| 源URL | [http://119.78.100.186/handle/113462/44765]  |
| 专题 | 近代物理研究所_空间辐射生物研究室 |
| 通讯作者 | Hu, Burong; Gao, Kun |
| 作者单位 | 1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China 2.Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Burong,Gao, Kun,Li, Ya,et al. Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway[J]. ONCOTARGET,2017,8:32807-32820. |
| APA | Hu, Burong,Gao, Kun,Li, Ya,Chen, Yaxiong,Pan, Dong,&Sun, Meng.(2017).Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway.ONCOTARGET,8,32807-32820. |
| MLA | Hu, Burong,et al."Coroglaucigenin enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway".ONCOTARGET 8(2017):32807-32820. |
入库方式： OAI收割
来源：近代物理研究所
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