Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice
文献类型：期刊论文
| 作者 | Quan, Dongqin5; Li, Xiaoman1,2,4,5; Ma, Dehui3; Zha, Xiaodan3; Pan, Dong1,2,4; Sun, Manji5; Hu, Burong1,4 ; Zhao, Baoquan5
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| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017-09-05 |
| 卷号 | 8页码:60789-60808 |
| 关键词 | ilomastat radiation-induced lung injury pneumonitis lung fibrosis MMPs Pathology Section |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.18487 |
| 英文摘要 | Lung injury is one of the pathological features in human or animal after radiation and the main side effect for patient after lung cancer radiotherapy. The efficient protective strategy still needs to exploit and the underlying mechanisms remain to be investigated. We found that the expression and activity of matrix metalloproteinases (MMPs) significantly increased at the early stage of radiation-induced lung injury (RILI). Pretreatment with Ilomastat, a synthetic inhibitor of MMPs, decreased the expression and activity of MMPs and significantly alleviated the lung inflammation and fibrosis in the irradiated mice, as well as enhanced the survival of irradiated mice. In addition, the levels of TGF-beta, IL-6, TNF-alpha and IL-1 beta in the tissues dramatically reduced in the irradiated mice pretreated with Ilomastat. Furthermore, our experiments in vitro also showed that radiation significantly increased the MMPs activity, and Ilomastat pretreatment inhibited the activity of MMPs activated by irradiation and increased the cell survival. It is the first report, to our knowledge, to demonstrate that Ilomastat is a potential effective reliever for RILI and MMPs may play important roles in the process of RILI. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; GROWTH-FACTOR-BETA ; IDIOPATHIC PULMONARY-FIBROSIS ; MATRIX METALLOPROTEINASES ; RADIATION PNEUMONITIS ; EXTRACELLULAR-MATRIX ; FACTOR-ALPHA ; MOUSE LUNG ; TGF-BETA ; CELLS |
| 资助项目 | National Key Scientific Instrument and Equipment Development Project of China[2012YQ03014210] ; National Key Scientific Instrument and Equipment Development Project of China[2012YQ03014211] ; National Natural Science Foundation of China[U1432121] ; National Natural Science Foundation of China[81173572] |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000409254200006 |
| 出版者 | IMPACT JOURNALS LLC |
| 资助机构 | National Key Scientific Instrument and Equipment Development Project of China ; National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/45569]  |
| 专题 | 近代物理研究所_空间辐射生物研究室 |
| 通讯作者 | Hu, Burong; Zhao, Baoquan |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Inner Mongolia Univ Nationalities, Coll Anim Sci & Technol, Tong Liao, Peoples R China 4.Key Lab Space Radiobiol Gansu Prov, Lanzhou, Gansu, Peoples R China 5.Acad Mil Med Sci, Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Quan, Dongqin,Li, Xiaoman,Ma, Dehui,et al. Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice[J]. ONCOTARGET,2017,8:60789-60808. |
| APA | Quan, Dongqin.,Li, Xiaoman.,Ma, Dehui.,Zha, Xiaodan.,Pan, Dong.,...&Zhao, Baoquan.(2017).Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice.ONCOTARGET,8,60789-60808. |
| MLA | Quan, Dongqin,et al."Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by gamma-ray irradiation in mice".ONCOTARGET 8(2017):60789-60808. |
入库方式： OAI收割
来源：近代物理研究所
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