A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation
文献类型：期刊论文
| 作者 | Li, Xiaoman1,2; Pan, Dong1,2; Du, Yarong2 ; Xue, Gang1,2; Zhu, Jiayun2; Chen, Yaxiong2; Ren, Zhenxin2; Hu, Burong2
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| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2015-05-28 |
| 卷号 | 361页码:121-127 |
| ISSN号 | 0304-3835 |
| 关键词 | Feedback Loop Mir-145 Dnmt3b Prostate Cancer Radiosensitivity |
| DOI | 10.1016/j.canlet.2015.02.046 |
| 文献子类 | Article |
| 英文摘要 | It is believed that epigenetic modification plays roles in cancer initiation and progression. Both microRNA and DNA methyltransferase are epigenetic regulation factors. It was found that miR-145 upregulates while DNMT3b downregulates in PD cells. Presence of any negative correlationship and their response to irradiation were investigated in the current study. We found that miR-145 downregulated DNMT3b expression by directly targeting the 3 '-UTR of DNMT3b mRNA and knockdown of DNMT3b increased expression of miR-145 via CpG island promoter hypomethylation, suggesting that there is a crucial crosstalk between miR-145 and DNMT3b via a double-negative feedback loop. Responses of the miR-145 and DNMT3b to irradiation are a negative correlation. We also found that either overexpression of miR-145 or knockdown of DNMT3b sensitized prostate cancer cells to X-ray radiation. Our findings enrich the complex relationships between miRNA and DNMTs in carcinogenesis and irradiation stress. It also sheds light on the potential combination of ionizing radiation and epigenetic regulation in prostate cancer therapy. (C) 2015 Elsevier Ireland Ltd. All rights reserved. |
| WOS关键词 | TUMOR-SUPPRESSOR ; DOWN-REGULATION ; GASTRIC-CANCER ; BREAST-CANCER ; LUNG-CANCER ; METHYLATION ; EXPRESSION ; DNMT3B ; MICRORNAS ; RADIATION |
| 资助项目 | 973 program from the Department of Chinese Science[2010CB834201] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | ELSEVIER IRELAND LTD |
| WOS记录号 | WOS:000352675500015 |
| 源URL | [http://119.78.100.186/handle/113462/47945]  |
| 专题 | 近代物理研究所_空间辐射生物研究室 |
| 通讯作者 | Hu, Burong |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaoman,Pan, Dong,Du, Yarong,et al. A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation[J]. CANCER LETTERS,2015,361:121-127. |
| APA | Li, Xiaoman.,Pan, Dong.,Du, Yarong.,Xue, Gang.,Zhu, Jiayun.,...&Hu, Burong.(2015).A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation.CANCER LETTERS,361,121-127. |
| MLA | Li, Xiaoman,et al."A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation".CANCER LETTERS 361(2015):121-127. |
入库方式： OAI收割
来源：近代物理研究所
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