Ring chromosome aberrations in human lymphocytes induced by 5-20 Gy carbon ion irradiation
文献类型：期刊论文
| 作者 | Wang Biqian1,2; Wang Zhuanzi1 ; Li Wenjian1; Xing Junzhen3
|
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 21页码:362-365 |
| 关键词 | Carbon ion beams Human lymphocytes Prematurely condensed ring chromosome |
| ISSN号 | 1001-8042 |
| 英文摘要 | In this paper, we study the biological response induced by heavy ions irradiation of high dose, human peripheral blood lymphocytes are irradiated in vitro by the carbon ions of LET=35 keV/mu m, and the chromosome aberrations at absorbed doses of 0-20 Gy are analyzed by the calyculin A-induced premature chromosome condensation (PCC). The frequencies of PCC-rings at the stage of G2/M-phase increase steeply with radiation doses up to 20 Gy at a rate of 0.017 Gy(-1). The G2-PCC index remains more than 5% up to 15 Gy, and 3% after 20 Gy, this is high enough to score a substantial number of chromosome spreads without dose-rate effect. The results show that the calyculin A-induced PCC technique is suitable for analyzing the chromosome damage induced by carbon ions irradiation of high dose. |
| WOS关键词 | PREMATURELY CONDENSED CHROMOSOMES ; SIMPLE BIODOSIMETRY METHOD ; DOSE RADIATION-EXPOSURE ; INDUCTION ; GAMMA ; PCC ; CELLS |
| 资助项目 | National Natural Science Foundation of China[10875153] ; Chinese Academy of Sciences for Postgraduate students[O906350YZ0] ; Chinese Academy of Sciences[O806260XB0] ; Chinese Academy of Sciences[O806270XBB] |
| WOS研究方向 | Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000287642700009 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Natural Science Foundation of China ; Chinese Academy of Sciences for Postgraduate students ; Chinese Academy of Sciences |
| 源URL | [http://119.78.100.186/handle/113462/33254]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Wang Zhuanzi |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Xiangning Hosp Shanxi Prov, Xiangning 042100, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Biqian,Wang Zhuanzi,Li Wenjian,et al. Ring chromosome aberrations in human lymphocytes induced by 5-20 Gy carbon ion irradiation[J]. NUCLEAR SCIENCE AND TECHNIQUES,2010,21:362-365. |
| APA | Wang Biqian,Wang Zhuanzi,Li Wenjian,&Xing Junzhen.(2010).Ring chromosome aberrations in human lymphocytes induced by 5-20 Gy carbon ion irradiation.NUCLEAR SCIENCE AND TECHNIQUES,21,362-365. |
| MLA | Wang Biqian,et al."Ring chromosome aberrations in human lymphocytes induced by 5-20 Gy carbon ion irradiation".NUCLEAR SCIENCE AND TECHNIQUES 21(2010):362-365. |
入库方式： OAI收割
来源：近代物理研究所
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