Spectroscopic assessment of argon gas discharge induced radiolysis of aqueous adenine and thymine
文献类型：期刊论文
| 作者 | Dang, Bingrong1 ; Wang, Xiangqin2; Yu, Zengliang2; Su, Xi2; Huang, Qing2
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| 刊名 | RADIATION PHYSICS AND CHEMISTRY
 |
| 出版日期 | 2011-12-01 |
| 卷号 | 80页码:1343-1351 |
| 关键词 | Plasma discharge Radiolysis Spectroscopy Adenine Thymine Liquid chromatography/mass spectrometry |
| ISSN号 | 0969-806X |
| DOI | 10.1016/j.radphyschem.2011.06.017 |
| 英文摘要 | Ionizing radiation influences life profoundly for it can modify genetic materials. It is a long-standing task to investigate the interaction between energetic particles and DNA together with its components such as nucleotides, nucleosides and bases so as to predict and assess the potential biological effects. In this study, argon gas discharge was employed to produce energetic ions and electrons. The gas discharge caused the radiolysis of aqueous bases and the involved reactions were analyzed by means of spectroscopic tools including UV-vis absorption, fluorescence and Fourier transformation infrared (FTIR) spectroscopy, also assisted by liquid chromatography/mass spectrometry (LC/MS). It was found that the discharge resulted in the adenine-derived lesions such as 4,6-diamino-5-formamidopyrimidine, 8-OH-Ade and 2-OH-Ade in the radiolysis of aqueous adenine, as well as the thymine-derived lesions such as thymine glycol, 5-hydroxy-6-hydrothymine and/or 6-hydroxy-5-hydrothymine, 5-hydroxymethyluracil and 5-formyluracil in the radiolysis of aqueous thymine. The study of radiosensitivity showed that adenine was more resistant to the discharge. The mechanisms of the involved reactions were studied in detail, confirming that the hydroxyl radical played a dominant role. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; RADIATION-INDUCED DAMAGE ; OXIDATIVE DNA-DAMAGE ; INDUCED BASE DAMAGE ; IONIZING-RADIATION ; TRANSFORMATION REACTIONS ; GAMMA-RADIOLYSIS ; STRAND BREAKAGE ; NUCLEIC-ACIDS ; CELLULAR-DNA |
| 资助项目 | Chinese Academy of Sciences[KJCX2-YW-N34-1] ; Natural Science Foundation of China[10975152] |
| WOS研究方向 | Chemistry ; Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000295665100009 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | Chinese Academy of Sciences ; Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/33320]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Huang, Qing |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Ion Beam Bioengn, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dang, Bingrong,Wang, Xiangqin,Yu, Zengliang,et al. Spectroscopic assessment of argon gas discharge induced radiolysis of aqueous adenine and thymine[J]. RADIATION PHYSICS AND CHEMISTRY,2011,80:1343-1351. |
| APA | Dang, Bingrong,Wang, Xiangqin,Yu, Zengliang,Su, Xi,&Huang, Qing.(2011).Spectroscopic assessment of argon gas discharge induced radiolysis of aqueous adenine and thymine.RADIATION PHYSICS AND CHEMISTRY,80,1343-1351. |
| MLA | Dang, Bingrong,et al."Spectroscopic assessment of argon gas discharge induced radiolysis of aqueous adenine and thymine".RADIATION PHYSICS AND CHEMISTRY 80(2011):1343-1351. |
入库方式： OAI收割
来源：近代物理研究所
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