Cell cycle suspension A novel process lurking in G(2) arrest
文献类型：期刊论文
| 作者 | Furusawa, Yoshiya3; Zhou, Guangming2 ; He, Jinpeng2; Li, Junhong1,2; Ye, Caiyong1,2; Zhou, Libin2; Zhu, Jiayun1,2; Wang, Jufang2; Mizota, Atsushi4
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| 刊名 | CELL CYCLE
 |
| 出版日期 | 2011-05-01 |
| 卷号 | 10页码:1468-1476 |
| 关键词 | cell cycle radiation suspension G(2) arrest cyclin B1 |
| ISSN号 | 1538-4101 |
| DOI | 10.4161/cc.10.9.15510 |
| 英文摘要 | Cell cycle checkpoint is a self-protective mechanism for cells to monitor genome integrity and ensure the high-fidelity transmission of genetic information to daughter cells. Insufficient function of cell cycle checkpoints has been demonstrated to partially account for tumor initiation, promotion and progression. In the ten melanoma cell lines that we tested in preliminary experiments, two human uveal melanoma cell lines, 92-1 and OCM-1, were found to be significantly different in terms of radiosensitivity but similar in DNA repair ability. Evident G(2) arrest was induced in both cell types and the maximum was reached at 16 h after irradiation regardless of X-rays or high-LET carbon beams. OCM-1 cells overrode the G(2) arrest and reentered the cell cycle right after reaching the maximum, whereas 92-1 could not. Upon 10 Gy of radiation, the cell cycle of 92-1 was suspended and remained unchanged for up to 5 d. The cell cycle suspension is a unique process lurking in G(2) arrest and related to cellular radiosensitivity. Its induction is dose-dependent and there is a dose threshold for it. The degradation of Cyclin B1 has been found related to the cell cycle suspension though, the mechanism of cell cycle suspension is still under investigation. Basing on our knowledge, this is the first report on cell cycle suspension and we present here a de novo mechanism to cellular radiosensitivity. Further clarification of the mechanism underlying cell cycle suspension is believed to be of significance in tumor radiosensitization or even direct tumor control. |
| WOS关键词 | HUMAN TUMOR-CELLS ; IONIZING-RADIATION ; CANCER-CELLS ; HELA-CELLS ; LINES ; CHECKPOINTS ; MELANOMA ; RADIOSENSITIVITY ; EXPRESSION ; APOPTOSIS |
| 资助项目 | Major State Basic Research Development Program of China (973 Program)[2010CB834201] ; Chinese Academy of Sciences[0760140BR0] |
| WOS研究方向 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000290145600025 |
| 出版者 | LANDES BIOSCIENCE |
| 资助机构 | Major State Basic Research Development Program of China (973 Program) ; Chinese Academy of Sciences |
| 源URL | [http://119.78.100.186/handle/113462/35058]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Zhou, Guangming |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Radiobiol Effects Grp, Lanzhou, Peoples R China 3.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 260, Japan 4.Juntendo Univ, Dept Ophthalmol, Urayasu Hosp, Urayasu, Japan |
| 推荐引用方式 GB/T 7714 | Furusawa, Yoshiya,Zhou, Guangming,He, Jinpeng,et al. Cell cycle suspension A novel process lurking in G(2) arrest[J]. CELL CYCLE,2011,10:1468-1476. |
| APA | Furusawa, Yoshiya.,Zhou, Guangming.,He, Jinpeng.,Li, Junhong.,Ye, Caiyong.,...&Mizota, Atsushi.(2011).Cell cycle suspension A novel process lurking in G(2) arrest.CELL CYCLE,10,1468-1476. |
| MLA | Furusawa, Yoshiya,et al."Cell cycle suspension A novel process lurking in G(2) arrest".CELL CYCLE 10(2011):1468-1476. |
入库方式： OAI收割
来源：近代物理研究所
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