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The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation

文献类型：期刊论文

作者Li, Wenjian6; Dang, Bingrong6; Xie, Yuexia1,4; Liu, Weili4; Konishi, Teruaki3; Tu, Wenzhi4; He, Mingyuan2,4; Dong, Chen4; Shao, Chunlin4; Hei, Tom K.5
刊名CANCER LETTERS
出版日期2015-07-10
卷号363页码:92-100
关键词Irradiation LET Multi-cell lines Secondary bystander effect Cytokine signals
ISSN号0304-3835
DOI10.1016/j.canlet.2015.04.013
英文摘要The abscopal effect could be an underlying factor in evaluating prognosis of radiotherapy. This study established an in vitro system to examine whether tumor-generated bystander signals could be transmitted by macrophages to further trigger secondary cellular responses after different irradiations, where human lung cancer NCI-H446 cells were irradiated with either gamma-rays or carbon ions and co-cultured with human macrophage U937 cells, then these U937 cells were used as a bystander signal transmitter and co-cultured with human bronchial epithelial cells BEAS-2B. Results showed that U937 cells were only activated by gamma-irradiated NCI-H446 cells so that the secondary injuries in BEAS-2B cells under carbon ion irradiation were weaker than gamma-rays. Both TNF-alpha and IL-1 alpha were involved in the gamma-irradiation induced secondary bystander effect but only TNF-alpha contributed to the carbon ion induced response. Further assay disclosed that IL-1 alpha but not TNF-alpha was largely responsible for the activation of macrophages and the formation of micronucleus in BEAS-2B cells. These data suggest that macrophages could transfer secondary bystander signals and play a key role in the secondary bystander effect of photon irradiation, while carbon ion irradiation has conspicuous advantage due to its reduced secondary injury. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
WOS关键词TUMOR-ASSOCIATED MACROPHAGES ; NITRIC-OXIDE ; IN-VIVO ; IONIZING-RADIATION ; ALPHA-PARTICLES ; CANCER-THERAPY ; 2ND CANCERS ; HUMAN-CELLS ; DNA-DAMAGE ; PROGRESSION
资助项目National Nature Science Foundation of China[11179002] ; National Nature Science Foundation of China[81273001] ; National Nature Science Foundation of China[31200631] ; National Nature Science Foundation of China[31300692] ; Research Fund for the Doctoral Program of Higher Education of China[20120071110057] ; MOST[2012YQ030142] ; International Open Laboratory on Space Radiation Research at NIRS ; NIRS-HIMAC of Japan[12J387] ; National Institutes of Health[CA 49062]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000355355900010
出版者ELSEVIER IRELAND LTD
资助机构National Nature Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education of China ; MOST ; International Open Laboratory on Space Radiation Research at NIRS ; NIRS-HIMAC of Japan ; National Institutes of Health
源URL[http://119.78.100.186/handle/113462/39832]  
专题近代物理研究所_生物物理研究室
通讯作者Shao, Chunlin
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Cent Lab, Shanghai 200127, Peoples R China
2.Jilin Univ, China Japan Union Hosp, Dept Radiat Oncol, Changchun 130033, Peoples R China
3.Natl Inst Radiol Sci, Res Dev & Support Ctr, Inage Ku, Chiba 2638555, Japan
4.Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
5.Columbia Univ Med Ctr, Dept Radiat Oncol, New York, NY 10032 USA
6.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Li, Wenjian,Dang, Bingrong,Xie, Yuexia,et al. The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation[J]. CANCER LETTERS,2015,363:92-100.
APA Li, Wenjian.,Dang, Bingrong.,Xie, Yuexia.,Liu, Weili.,Konishi, Teruaki.,...&Uchihori, Yukio.(2015).The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation.CANCER LETTERS,363,92-100.
MLA Li, Wenjian,et al."The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation".CANCER LETTERS 363(2015):92-100.

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来源：近代物理研究所

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