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G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation

文献类型：期刊论文

作者Dang, Bingrong4; Li, Wenjian4; Shao, Chunlin2; Konishi, Teruaki3; Dong, Chen2; Kobayashi, Alisa3; Tu, Wenzhi2; Furusawa, Yoshiya3; Uchihori, Yukio3; Xie, Yuexia1,2
刊名MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
出版日期2016
卷号795页码:1-6
关键词RIBE Carbon ion Cell cycle DNA-PKcs ATM
ISSN号1383-5718
DOI10.1016/j.mrgentox.2015.11.001
英文摘要Accumulated evidence has shown that radiation-induced bystander effect (RIBE) may have significant implications to the efficiency of radiotherapy. Although cellular radiosensitivity relies on cell cycle status, it is largely unknown how about the relationship between RIBE and cell cycle distribution, much less the underlying mechanism. In the present study, the lung cancer A549 cells were synchronized into different cell cycle phases of G(1), S and G(2)/M and irradiated with high linear energy transfer (LET) carbon ions. By treating nonirradiated cells with the conditioned medium from these irradiated cells, it was found that the G(2)-M phase cells had the largest contribution to RIBE. Meanwhile, the activity of DNA-PKcs but not ATM was increased in the synchronized G(2)-M phase cells in spite of both of them were activated in the asynchronous cells after carbon ion irradiation. When the G(2)-M phased cells were transferred with DNA-PKcs siRNA and ATM siRNA individually or treated with an inhibitor of either DNA-PKcs or ATM before carbon ion irradiation, the RIBE was effectively diminished. These results provide new evidence linking cell cycle to bystander responses and demonstrate that DNA-PKcs and ATM are two associated factors in co-regulating G(2)-M phase-related bystander effects. (C) 2015 Elsevier B.V. All rights reserved.
WOS关键词DEPENDENT PROTEIN-KINASE ; STRAND BREAK REPAIR ; CATALYTIC SUBUNIT ; ALPHA-PARTICLES ; DAMAGE RESPONSE ; GLIOMA-CELLS ; NITRIC-OXIDE ; INTERCELLULAR COMMUNICATION ; HUMAN FIBROBLASTS ; TUMOR-CELLS
资助项目National Nature Science Foundation of China[11179002] ; National Nature Science Foundation of China[81273001] ; National Nature Science Foundation of China[31400719] ; MOST Project[2012YQ030142] ; Research Fund for the Doctoral Program of Higher Education of China[20120071110057] ; Shanghai Municipal Commission of Health and Family Planning[20144Y0203] ; NIRS International Open Laboratory program on Space Radiation Research ; Research Project with Heavy Ions at NIRS-HIMAC of Japan[12J387]
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology
语种英语
WOS记录号WOS:000369454100001
出版者ELSEVIER SCIENCE BV
资助机构National Nature Science Foundation of China ; MOST Project ; Research Fund for the Doctoral Program of Higher Education of China ; Shanghai Municipal Commission of Health and Family Planning ; NIRS International Open Laboratory program on Space Radiation Research ; Research Project with Heavy Ions at NIRS-HIMAC of Japan
源URL[http://119.78.100.186/handle/113462/41698]  
专题近代物理研究所_生物物理研究室
通讯作者Shao, Chunlin
作者单位1.Shanghai Jiao Tong Univ, Renji Hosp, Cent Lab, Shanghai 200001, Peoples R China
2.Fudan Univ, Inst Radiat Med, Shanghai 200032, Peoples R China
3.Natl Inst Radiol Sci, Res Dev & Support Ctr, Inage Ku, Chiba 2638555, Japan
4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Dang, Bingrong,Li, Wenjian,Shao, Chunlin,et al. G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,2016,795:1-6.
APA Dang, Bingrong.,Li, Wenjian.,Shao, Chunlin.,Konishi, Teruaki.,Dong, Chen.,...&Xie, Yuexia.(2016).G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation.MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS,795,1-6.
MLA Dang, Bingrong,et al."G(2)-M phase-correlative bystander effects are co-mediated by DNA-PKcs and ATM after carbon ion irradiation".MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 795(2016):1-6.

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来源：近代物理研究所

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