Anti-tumor effects of (1 -> 3)-beta-D-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice
文献类型:期刊论文
作者 | Chen, Yafei1; Mo, Li1; Li, Wenjian2![]() |
刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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出版日期 | 2017-02-01 |
卷号 | 95页码:385-392 |
关键词 | (1 -> 3)-beta-D-Glucan Anti-tumor S180-bearing mice Immunomodulatory Apoptosis |
ISSN号 | 0141-8130 |
DOI | 10.1016/j.ijbiomac.2016.10.106 |
英文摘要 | (1 -> 3)-beta-D-Glucan from Saccharomyces cerevisiae is a typical polysaccharide with various biological effects and is considered a candidate for the prevention and treatment of cancer in vitro. Research into the function of (1 -> 3)-beta-D-glucan in tumor-bearing animals in vivo, however, is limited. Here, we investigated the effects of (1 -> 3)-beta-D-glucan from S. cerevisiae on S180 tumor-bearing mice and on the immunity of the tumor-bearing host. The molecular mechanisms underlying the observed effects were investigated. (1 -> 3)-beta-D-Glucan was shown to exert anti-tumor effects without toxicity in normal mouse cells. The volume and weight of S180 tumors decreased dramatically following treatment with (1 -> 3)-beta-D-glucan, and treatment with the polysaccharide was furthermore shown to increase the tumor inhibition rate in a dose-dependent manner. Spleen index, T lymphocyte subsets (CD4 and CD8), as well as interleukins (IL)-2, (IL-2, IL-6), and tumor necrosis factor-a were assayed to detect the immunoregulatory and anti-tumor effects after (1 -> 3)-beta-D-glucan intragastrical administration. (1 -> 3)-S-D-Glucan was shown to significantly potentiate the mouse immune responses by, among other effects, decreasing the ratio of CD4 to CD8. The expression levels of IL-2, IL-6, and TNF-alpha were also significantly increased by (1 -> 3)-beta-D-glucan. These results suggest that (1 -> 3)-beta-D-glucan enhances the host's immune function during the tumor inhibition process. S180 tumor cells treated with (1 -> 3)-beta-D-glucan also exhibited significant apoptotic characteristics. (1 -> 3)-beta-D-glucan increased the ratio of Box to Bcl-2 at the translation level by up-regulating Bax expression and down-regulating Bcl-2 expression, resulting in the initiation of cell apoptosis in S180 tumor-bearing mice. Taken together, these results indicate that the anti-tumor effects exerted by (1 -> 3)-beta-D-glucan may be attributed to the polysaccharide's immunostimulating properties and apoptosis-inducing features. Further investigation into these properties and their associated mechanisms will contribute to the development of potent polysaccharide-based anti-tumor agents. (C) 2016 Elsevier B.V. All rights reserved. |
WOS关键词 | CELL-MEDIATED-IMMUNITY ; BETA-GLUCAN ; CANCER-IMMUNOTHERAPY ; MONOCLONAL-ANTIBODY ; CD4/CD8 RATIO ; CYCLE ARREST ; MCF-7 CELLS ; POLYSACCHARIDES ; APOPTOSIS ; SUPPRESSION |
资助项目 | Natural Science Fund for Distinguished Young Scholars of the Hebei Province of China[C2015202340] ; Fund for Outstanding Talents of Hebei Province of China[C201400305] ; Natural Science Fund of Hebei Province[C2013202244] ; National Natural Science Fund of China[11247010] ; National Natural Science Fund of China[31400711] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
语种 | 英语 |
WOS记录号 | WOS:000392903000050 |
出版者 | ELSEVIER SCIENCE BV |
资助机构 | Natural Science Fund for Distinguished Young Scholars of the Hebei Province of China ; Fund for Outstanding Talents of Hebei Province of China ; Natural Science Fund of Hebei Province ; National Natural Science Fund of China |
源URL | [http://119.78.100.186/handle/113462/44272] ![]() |
专题 | 近代物理研究所_生物物理研究室 |
通讯作者 | An, Hailong; Zhan, Yong |
作者单位 | 1.Hebei Univ Technol, Sch Sci, Inst Biophys, Key Lab Mol Biophys Hebei Prov, Tianjin 300401, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Yafei,Mo, Li,Li, Wenjian,et al. Anti-tumor effects of (1 -> 3)-beta-D-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,95:385-392. |
APA | Chen, Yafei.,Mo, Li.,Li, Wenjian.,Guo, Shuai.,Wang, Xuzhao.,...&Zhan, Yong.(2017).Anti-tumor effects of (1 -> 3)-beta-D-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,95,385-392. |
MLA | Chen, Yafei,et al."Anti-tumor effects of (1 -> 3)-beta-D-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 95(2017):385-392. |
入库方式: OAI收割
来源:近代物理研究所
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