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Caspase-9: structure, mechanisms and clinical application

文献类型：期刊论文

作者Zhang, Pengcheng1,2,3,4; Li, Ping1,3,4; Zhou, Libin4; Zhao, Ting1,3,4; Liu, Xiongxiong1,3,4; Liu, Yan1,2,3,4; Zheng, Xiaogang1,2,3,4; Li, Qiang1,3,4
刊名ONCOTARGET
出版日期2017
卷号8页码:23996-24008
关键词caspase-9 apoptosis phosphorylation alternative splicing iCasp9
ISSN号1949-2553
DOI10.18632/oncotarget.15098
英文摘要As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. Caspase-9 is activated on the apoptosome complex to remain catalytic status and is thought of involving homo-dimerization monomeric zymogens. Failing to activate caspase-9 has profound physiological and pathophysiological outcomes, leading to degenerative and developmental disorders even cancer. To govern the apoptotic commitment process appropriately, plenty of proteins and small molecules involved in regulating caspase-9. Therefore, this review is to summarize recent pertinent literature on the comprehensive description of the molecular events implicated in caspase-9 activation and inhibition, as well as the clinical trials in progress to give deep insight into caspase-9 for suppressing cancer. We hope that our concerns will be helpful for further clinical studies addressing the roles of caspase-9 and its regulators demanded to identify more effective solutions to overcome intrinsic apoptosis-related diseases especially cancer.
WOS关键词DEATH PROTEASE CASPASE-9 ; INDUCED PROXIMITY MODEL ; PRE-MESSENGER-RNA ; CYTOCHROME-C ; CELL-DEATH ; T-CELLS ; SUICIDE-GENE ; PROSTATE-CANCER ; SAFETY SWITCH ; NITRIC-OXIDE
资助项目Key Project of National Natural Science Foundation of China[U1232207] ; National Key Research and Development Program of the Ministry of Science and Technology of China[2016YFC0904700] ; National Key Technology Support Program of the Ministry of Science and Technology of China[2015BAI01B11] ; National Natural Science Foundation of China[11305223] ; National Natural Science Foundation of China[11505245] ; Western Talents Program of the Chinese Academy of Sciences[Y562020XB0]
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000398211100139
出版者IMPACT JOURNALS LLC
资助机构Key Project of National Natural Science Foundation of China ; National Key Research and Development Program of the Ministry of Science and Technology of China ; National Key Technology Support Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Western Talents Program of the Chinese Academy of Sciences
源URL[http://119.78.100.186/handle/113462/44621]  
专题近代物理研究所_生物物理研究室
通讯作者Li, Qiang
作者单位1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China
4.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Pengcheng,Li, Ping,Zhou, Libin,et al. Caspase-9: structure, mechanisms and clinical application[J]. ONCOTARGET,2017,8:23996-24008.
APA Zhang, Pengcheng.,Li, Ping.,Zhou, Libin.,Zhao, Ting.,Liu, Xiongxiong.,...&Li, Qiang.(2017).Caspase-9: structure, mechanisms and clinical application.ONCOTARGET,8,23996-24008.
MLA Zhang, Pengcheng,et al."Caspase-9: structure, mechanisms and clinical application".ONCOTARGET 8(2017):23996-24008.

入库方式： OAI收割

来源：近代物理研究所

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