Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells
文献类型：期刊论文
| 作者 | Zhou, Guangming2,6 ; Li, He2,5,6; Wang, Jufang1,2,6; Sun, Fang2,5,6; Zhang, Xurui2,5,6; Zhou, Xia3,4; Hua, Junrui2,6; Zhang, Yanan2,6; Wang, Bing2,5,6; Hu, Wentao2,6
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| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
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| 出版日期 | 2017 |
| 卷号 | 10页码:4639-4648 |
| 关键词 | Heavy-ions X-rays glioma cancer stem cells irradiation |
| ISSN号 | 1940-5901 |
| 英文摘要 | Heavy-ion therapy has demonstrated significant benefits such as well-defined range, small entrance dose and high relative biological effectiveness, but the characteristics of heavy-ion induced radio-biological effects on cancer stem cells is not completely clear. We used human glioma cancer stem cells and glioma virus-induced mice model irradiated by carbon ions or X-rays to investigate whether heavy ions offering a radio-biological advantage, by effectively eliminate cancer stem cells, in comparison with conventional X-rays. In in vitro experiments, the repair rate of DNA damage generated by 2 Gy carbon ions was lower than that by X-rays in glioma stem cells. Micronucleus assay showed the micronuclei frequency induced by carbon ions was higher than that by X-rays. MTT assay showed the cellular viability of glioma stem cells irradiated by 1-4 Gy carbon ions was lower than that by X-rays. Results of in vivo experiment demonstrated carbon-ion radiation could significantly reduce the radio of CD133(+) glioma stem-like cells compared with X-rays. In conclusion, carbon ions showed radio-biological advantage over X-rays by effectively eliminate glioma cancer stem cells both in vitro and in vivo, which have significant importance in understanding the high relative biological effectiveness related to heavy-ion therapy. |
| WOS关键词 | MTT ASSAY ; DNA-DAMAGE ; CANCER ; THERAPY ; RADIOTHERAPY ; REPAIR ; GLIOBLASTOMA ; INDUCTION ; SURVIVAL ; TUMORS |
| 资助项目 | National Natural Science Foundation of China[31270895] ; National Natural Science Foundation of China[U1232125] ; National Natural Science Foundation of China[31400723] ; National Natural Science Foundation of China[11405235] ; National Natural Science Foundation of China[11405232] ; National Natural Science Foundation of China[11335011] |
| WOS研究方向 | Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000400552900042 |
| 出版者 | E-CENTURY PUBLISHING CORP |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/45265]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Wang, Jufang |
| 作者单位 | 1.Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Gansu Key Lab Space Radiobiol, 509 Nanchang Rd, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, 509 Nanchang Rd, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Guangming,Li, He,Wang, Jufang,et al. Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2017,10:4639-4648. |
| APA | Zhou, Guangming.,Li, He.,Wang, Jufang.,Sun, Fang.,Zhang, Xurui.,...&Zhao, Xudong.(2017).Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,10,4639-4648. |
| MLA | Zhou, Guangming,et al."Comparisons between bio-radiation effects of X-rays and carbon-ion irradiation on glioma stem cells".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 10(2017):4639-4648. |
入库方式： OAI收割
来源：近代物理研究所
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