Radiation-induced cellular senescence results from a slippage of long-term G(2) arrested cells into G(1) phase
文献类型：期刊论文
| 作者 | Ye, Caiyong1,2; Wang, Jufang2 ; Zhang, Xurui1,2; Zhou, Guangming2; Wan, Jianghua2; Chang, Lei1,2; Hu, Wentao1,2; Bing, Zhitong2; Zhang, Sheng1,2; Li, Junhong1,2
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| 刊名 | CELL CYCLE
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| 出版日期 | 2013-05-01 |
| 卷号 | 12页码:1424-1432 |
| 关键词 | Ionizing Radiation g(2) Slippage Senescence Cell Cycle Checkpoint Dna Damage Response Mitotic Slippage |
| ISSN号 | 1538-4101 |
| DOI | 10.4161/cc.24528 |
| 文献子类 | Article |
| 英文摘要 | Diploid cells undergoing senescence and mitotic slippage have been reported in the literature. However, the mechanisms triggering senescence in long-term G(2)-arrested cells are currently unclear. Previously, we reported that the cell cycle of the human uveal melanoma cell line, 92-1, is suspended for up to 6 d upon exposure to 10 Gy ionizing radiation (IR), followed by senescence. In the current study, we initially distinguished senescence in long-term blocked 92-1 cells from mitotic slippage by confirming the blockage of cells in the G(2) phase. We subsequently showed that the genes essential for G(2)-M transition are prematurely downregulated at both the transcriptional and translational levels. Furthermore, levels of the G(1)-specific markers, Cyclin D1 and Caveolin-1, were distinctly increased, while S/G(2)-specific markers, Cyclin B1 and Aurora A, were significantly downregulated. These findings collectively imply that long-term G(2)-arrested cells undergo senescence via G(2) slippage. To our knowledge, this is the first study to report that the cellular process of G(2) slippage is the mechanism responsible for senescence of cells under long-term G(2) arrest. |
| WOS关键词 | HUMAN DIPLOID CELLS ; CYCLIN D1 EXPRESSION ; DNA-DAMAGE-RESPONSE ; MAMMALIAN-CELLS ; CANCER ; POLYPLOIDY ; CHECKPOINT ; ENDOREPLICATION ; ACTIVATION ; G2 |
| 语种 | 英语 |
| WOS记录号 | WOS:000322758600017 |
| 出版者 | LANDES BIOSCIENCE |
| 源URL | [http://119.78.100.186/handle/113462/48297]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Wang, Jufang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Modem Phys, Dept Space Radiobiol, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Caiyong,Wang, Jufang,Zhang, Xurui,et al. Radiation-induced cellular senescence results from a slippage of long-term G(2) arrested cells into G(1) phase[J]. CELL CYCLE,2013,12:1424-1432. |
| APA | Ye, Caiyong.,Wang, Jufang.,Zhang, Xurui.,Zhou, Guangming.,Wan, Jianghua.,...&He, Jinpeng.(2013).Radiation-induced cellular senescence results from a slippage of long-term G(2) arrested cells into G(1) phase.CELL CYCLE,12,1424-1432. |
| MLA | Ye, Caiyong,et al."Radiation-induced cellular senescence results from a slippage of long-term G(2) arrested cells into G(1) phase".CELL CYCLE 12(2013):1424-1432. |
入库方式： OAI收割
来源：近代物理研究所
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