Simulated studies on the biological effects of space radiation on quiescent human fibroblasts
文献类型：期刊论文
| 作者 | Hu, Wentao2,4; Zhou, Guangming2 ; Wang, Tieshan3; Wang, Jufang2; Li, Yinghui1; Li, He2; Matsumoto, Yoshitaka5; Liu, Cuihua5; Hirayama, Ryoichi5; Furusawa, Yoshiya5
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| 刊名 | ADVANCES IN SPACE RESEARCH
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| 出版日期 | 2013-10-01 |
| 卷号 | 52页码:1314-1319 |
| 关键词 | Quiescent Cells Space Radiation Hze Particles Risk Assessment |
| ISSN号 | 0273-1177 |
| DOI | 10.1016/j.asr.2013.06.030 |
| 文献子类 | Article |
| 英文摘要 | High charge and energy (HZE) particles are severe risk to manned long-term outer space exploration. Studies on the biological effects of space HZE particles and the underlying mechanisms are essential to the accurate risk assessment and the development of efficient countermeasure. Since majority of the cells in human body stay quiescent (G0 phase), in this study, we established G0 cell and G1 cell models by releasing human normal embryonic lung fibroblast cells from contact inhibition and studied the radiation toxicity of various kinds of HZE particles. Results showed that all of the particles were dose-dependently lethal and G0 cells were more radioresistant than G1 cells. We also found that 53BP1 foci were induced in a LET- and fluence-dependent manner and fewer foci were induced in G0 cells than G1 cells, however, the decrease of foci in 24 h after irradiation was highly relevant to the type of particles. These results imply that even though health risk of space radiation is probably overestimated by the data obtained with exponentially growing cells, whose radiosensitivity is similar to G1 cells, the risk of space HZE particles is un-ignorable and accurate assessment and mechanistic studies should be deepened. The diverse abilities of G0 cells and G1 cells in repairing DNA damages induced by HZE particles emphasize the importance in studying the impact of HZE particles on DNA damage repair pathways. (C) 2013 COSPAR. Published by Elsevier Ltd. All rights reserved. |
| WOS关键词 | CHROMOSOME-ABERRATIONS ; IONIZING-RADIATION ; HUMAN-LYMPHOCYTES ; CELL-CYCLE ; REPAIR ; IONS ; IRRADIATION ; DAMAGE |
| 资助项目 | National Natural Science Foundations of China[10979062] ; National Natural Science Foundations of China[U1232125] ; National Natural Science Foundations of China[31270895] |
| WOS研究方向 | Astronomy & Astrophysics ; Geology ; Meteorology & Atmospheric Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000325045800012 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.186/handle/113462/48311]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Zhou, Guangming |
| 作者单位 | 1.Astronaut Ctr China, State Key Lab Space Med Fundamentat & Applicat, Beijing 100094, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Hu, Wentao,Zhou, Guangming,Wang, Tieshan,et al. Simulated studies on the biological effects of space radiation on quiescent human fibroblasts[J]. ADVANCES IN SPACE RESEARCH,2013,52:1314-1319. |
| APA | Hu, Wentao.,Zhou, Guangming.,Wang, Tieshan.,Wang, Jufang.,Li, Yinghui.,...&Ding, Nan.(2013).Simulated studies on the biological effects of space radiation on quiescent human fibroblasts.ADVANCES IN SPACE RESEARCH,52,1314-1319. |
| MLA | Hu, Wentao,et al."Simulated studies on the biological effects of space radiation on quiescent human fibroblasts".ADVANCES IN SPACE RESEARCH 52(2013):1314-1319. |
入库方式： OAI收割
来源：近代物理研究所
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