Risk assessment of space radiation during manned space flights
文献类型：期刊论文
| 作者 | Zhu, Mingyue1; Wang, Jufang1 ; Zhou, Guangming1; Xu, Dan1; Liu, Tingting1; Pei, Hailong1,2; Li, He1
|
| 刊名 | RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 25页码:S17-S21 |
| 关键词 | Space Radiation Early Effects Late Effects Radiation Protection |
| ISSN号 | 2037-4631 |
| DOI | 10.1007/s12210-013-0277-6 |
| 文献子类 | Article |
| 英文摘要 | During a long-term exploration in space, astronauts will be constantly exposed to space radiation which contains various types of low dose-rate heavy particles. Although the fluxes of these heavy ions are very small, the heavy ions can cause severe biological effects including early effects and late effects. This short review will discuss the biological effects induced by space radiation and introduce a new anti-radiation agent we have developed. We synthesized a class of reactive oxygen species scavengers called GANRA-5 with lowly toxic but high radio-protective effect to both heavy ions and X-rays. GANRA-5 can protect cells from X-rays and carbon ions induced cell killing by significantly reducing the amount of free radical production therefor reduce double-strand breaks and genomic instability. In vivo, GANRA-5 can effectively protect the mice from the damage induced by X-rays irradiation by enhancing superoxide dismutase activities. In brief, GANRA-5 is potentially applicable in space flight. |
| WOS关键词 | GALACTIC COSMIC-RAYS ; ASTRONAUTS ; BONE ; EXPLORATION ; EXPOSURE ; WR-2721 ; MICE ; RADIOPROTECTION ; CARCINOGENESIS ; IRRADIATION |
| 资助项目 | National Natural Science Foundation of China[10979062] ; National Natural Science Foundation of China[31270895] ; National Natural Science Foundation of China[U1232125] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000332688700006 |
| 出版者 | SPRINGER-VERLAG ITALIA SRL |
| 源URL | [http://119.78.100.186/handle/113462/49217]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Zhou, Guangming |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Mingyue,Wang, Jufang,Zhou, Guangming,et al. Risk assessment of space radiation during manned space flights[J]. RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI,2014,25:S17-S21. |
| APA | Zhu, Mingyue.,Wang, Jufang.,Zhou, Guangming.,Xu, Dan.,Liu, Tingting.,...&Li, He.(2014).Risk assessment of space radiation during manned space flights.RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI,25,S17-S21. |
| MLA | Zhu, Mingyue,et al."Risk assessment of space radiation during manned space flights".RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI 25(2014):S17-S21. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。