The role of autophagy in cell survival from heavy ion irradiation in the plateau region
文献类型：期刊论文
| 作者 | Zhang Dong-Zhi3; Li Wen-Jian2 ; Xia Jie-Fang1,2; Wang Zhuan-Zi2; Liu Qing-Fang2; Wei Wei2
|
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2014-06-01 |
| 卷号 | 25 |
| 关键词 | Carbon Ions Irradiation Cell Survival Apoptosis Autophagy |
| ISSN号 | 1001-8042 |
| 文献子类 | Article |
| 英文摘要 | To study cytotoxic effect of heavy ion irradiation in the plateau region, and investigate whether autophagy induced by heavy ion irradiation is cytoprotective, HeLa cells were irradiated with 350 MeV/u carbon ions beams, and the clonogenic survival was analyzed. The results showed that cell survival decreased with increasing doses. It was also found that G2/M-phase cells increased, and the autophagy-related activity was significantly higher than the control. When autophagy was blocked by 3-methyladenine in carbon-ion irradiated cells, G2/M phase arrest and the percentage of apoptosis cells were further elevated, and cell survival decreased significantly, indicating the induction of cytoprotective autophagy by carbon-ion irradiation. Our results demonstrated that autophagy induced by carbon ion irradiation provided a self-protective mechanism in HeLa cells, short-time inhibition of autophagy before carbon-ion irradiation could enhance radiation cytotoxicity in HeLa cells. |
| WOS关键词 | BREAST-TUMOR CELLS ; IONIZING-RADIATION ; CARCINOMA-CELLS ; CANCER ; DEATH ; RADIOTHERAPY |
| 资助项目 | West Light Foundation of the Chinese Academy of Sciences[Y306010XBO] |
| WOS研究方向 | Nuclear Science & Technology ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000339366300008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.186/handle/113462/49653]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Xia Jie-Fang |
| 作者单位 | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Gansu Prov People Hosp, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Dong-Zhi,Li Wen-Jian,Xia Jie-Fang,et al. The role of autophagy in cell survival from heavy ion irradiation in the plateau region[J]. NUCLEAR SCIENCE AND TECHNIQUES,2014,25. |
| APA | Zhang Dong-Zhi,Li Wen-Jian,Xia Jie-Fang,Wang Zhuan-Zi,Liu Qing-Fang,&Wei Wei.(2014).The role of autophagy in cell survival from heavy ion irradiation in the plateau region.NUCLEAR SCIENCE AND TECHNIQUES,25. |
| MLA | Zhang Dong-Zhi,et al."The role of autophagy in cell survival from heavy ion irradiation in the plateau region".NUCLEAR SCIENCE AND TECHNIQUES 25(2014). |
入库方式： OAI收割
来源：近代物理研究所
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