MicroRNAs regulate bone metabolism
文献类型：期刊论文
| 作者 | Ji, Yinli2; Liu, Tingting4 ; Zhang, Jiangyan3; Li, Yi1; Xu, Dan4; Zhao, Xin1; Zhou, Guangming4; Xie, Xiaodong1; Wang, Jufang4
|
| 刊名 | JOURNAL OF BONE AND MINERAL METABOLISM
 |
| 出版日期 | 2014-05-01 |
| 卷号 | 32页码:221-231 |
| 关键词 | Mirnas Osteoporosis Osteoblasts Osteoclasts |
| ISSN号 | 0914-8779 |
| DOI | 10.1007/s00774-013-0537-7 |
| 文献子类 | Review |
| 英文摘要 | Osteoporosis is caused by an unbalance between bone formation and bone resorption. Bone homeostasis is regulated by intricate mechanisms. Recently, a novel class of regulatory factors termed microRNAs (miRNAs) has been found to play a crucial role in cell cycle control, apoptosis and other cellular processes including metabolism and differentiation. Published data have shown that some miRNAs regulate bone homeostasis, including bone formation, resorption, remodeling, repair and bone-related disease, by regulating the expression of certain cytokines and transcription factors. This review highlights the current knowledge of miRNAs and their involvement in the regulation of bone formation, bone resorption and the pathways regulating the progression of osteoporosis. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; HUMAN ADIPOSE-TISSUE ; PROMOTES OSTEOBLAST DIFFERENTIATION ; TRANSCRIPTION FACTOR OSTERIX ; OSTEOGENIC DIFFERENTIATION ; UP-REGULATION ; OSTEOPOROTIC FRACTURES ; CAENORHABDITIS-ELEGANS ; LINEAGE PROGRESSION ; PROTEIN EXPRESSION |
| WOS研究方向 | Endocrinology & Metabolism ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000335654900001 |
| 出版者 | SPRINGER JAPAN KK |
| 源URL | [http://119.78.100.186/handle/113462/49765]  |
| 专题 | 近代物理研究所_生物物理研究室 |
| 通讯作者 | Xie, Xiaodong |
| 作者单位 | 1.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 2.Gansu Hualing Biotechnol Res Ctr, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Inst Pathol, Sch Basic Med Sci, Lanzhou 730000, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Dept Space Radiobiol, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Yinli,Liu, Tingting,Zhang, Jiangyan,et al. MicroRNAs regulate bone metabolism[J]. JOURNAL OF BONE AND MINERAL METABOLISM,2014,32:221-231. |
| APA | Ji, Yinli.,Liu, Tingting.,Zhang, Jiangyan.,Li, Yi.,Xu, Dan.,...&Wang, Jufang.(2014).MicroRNAs regulate bone metabolism.JOURNAL OF BONE AND MINERAL METABOLISM,32,221-231. |
| MLA | Ji, Yinli,et al."MicroRNAs regulate bone metabolism".JOURNAL OF BONE AND MINERAL METABOLISM 32(2014):221-231. |
入库方式： OAI收割
来源：近代物理研究所
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