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The effects of x-ray radiation on the eye development of zebrafish

文献类型：期刊论文

作者Zhou R(周蓉)
刊名Human and Experimental Toxicology
出版日期2014-10-15
卷号33期号:10页码:1040-1050
关键词X-Ray eye development zebrafish cell apoptosis reactive oxygen species microophthalmia
ISSN号0960-3271
DOI10.1177/0960327114522278
英文摘要The toxic effects of x-ray radiation on eye development was measured using zebrafish as a model organism. Zebrafish embryos at 8 h post-fertilization (hpf) were irradiated using X-rays at doses of 1, 2, 4, and 8 Gy. At 24 and 48 hpf, x-ray radiation induced a significant increase in reactive oxygen species (ROS) content and cell apoptotic signals. Both of these increases were dose dependent and there were significant positive relationships between them at 24 hpf. At 48 and 72 hpf, the increase of ROS concentration can be eliminated by increasing activities of superoxide dismutase and catalase. Although the ROS generated by x-ray radiation caused a significant increase in cell apoptosis at 24 and 48 hpf, the cellular layers of the retina and lens formation in the irradiated groups were not significantly disrupted at 144 hpf compared with the control group, with the exception of a heterogeneous distribution of the cells in inner nuclear cell layer and a significant decrease in the diameters of whole eyes after 8 Gy irradiation. X-Ray radiation at later stages of gastrulation may not cause distinct optic complications; however, there is still a risk of microophthalmia at high doses of irradiation.
WOS关键词STRAND BREAK REPAIR ; TUMOR STEM-CELLS ; OXIDATIVE STRESS ; IONIZING-RADIATION ; VERTEBRATE EMBRYO ; DANIO-RERIO ; DNA-DAMAGE ; EXPOSURE ; MODEL ; IRRADIATION
资助项目Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Scientific Technology Research Projects of Gansu Province[0806RJYA020]
WOS研究方向Toxicology
语种英语
WOS记录号WOS:000343382400005
出版者SAGE PUBLICATIONS LTD
公开日期2014-12-17
源URL[http://ir.impcas.ac.cn/handle/113462/12574]  
专题近代物理研究所_辐射医学研究室
推荐引用方式
GB/T 7714		 Zhou R. The effects of x-ray radiation on the eye development of zebrafish[J]. Human and Experimental Toxicology,2014,33(10):1040-1050.
APA Zhou R.(2014).The effects of x-ray radiation on the eye development of zebrafish.Human and Experimental Toxicology,33(10),1040-1050.
MLA Zhou R."The effects of x-ray radiation on the eye development of zebrafish".Human and Experimental Toxicology 33.10(2014):1040-1050.

入库方式： OAI收割

来源：近代物理研究所

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