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Dynamically-enhanced retention of gold nanoclusters in HeLa cells following X-rays exposure: A cell cycle phase-dependent targeting approach

文献类型：期刊论文

作者Liu, Yan1,4,5,6; Chen, Weiqiang1,5,6; Zhang, Pengcheng1,4,5,6; Jin, Xiaodong1,5,6; Liu, Xinguo1,5,6; Li, Ping1,5,6; Li, Feifei1,4,5,6; Zhang, Hongpeng5; Zou, Guozhang2,3; Li, Qiang1,5,6
刊名RADIOTHERAPY AND ONCOLOGY
出版日期2016-06-01
卷号119页码:544-551
关键词Ionizing radiation Nano-agents Cell cycle Cellular uptake Synergistic chemo-radiotherapy
ISSN号0167-8140
DOI10.1016/j.radonc.2016.04.033
英文摘要Background and purpose: Cell cycle phase could affect the cellular uptake of nanoparticles. Based on the fact that ionizing radiation exposure can delay cell cycle progression including inducing G2/M phase arrest, we propose that ionizing radiation exposure is a cell cycle phase-dependent targeting approach for intracellular delivery of nano-agents in tumor cells. Materials and methods: We synthesized luminescent gold nanoclusters (AuNCs) using a one-pot green synthetic method. Subsequently, we used the as-prepared AuNCs as both "nano-agents" and fluorescent trafficking probes for our study using human cervical carcinoma HeLa cells. Estimating the cellular uptake of AuNCs and cell cycle analysis were performed following X-rays irradiation and cell synchronization. Results: Our work showed that X-rays irradiation could delay the division of HeLa cells and thereby enhance the retention of AuNCs in HeLa cells, which is a reverse strategy compared with other studies on synergistic nano-radiotherapy. Our results demonstrated that the cell cycle synchronization influenced the cellular uptake processes of AuNCs, suggesting that dynamic cell cycle progression could affect the cellular uptake kinetics of AuNCs. Conclusion: We consider that the radiation-induced cell division delay might provide a possible mechanism underlying the enhanced effect for the cellular uptake of AuNCs in irradiated HeLa cells. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
WOS关键词NANOPARTICLE UPTAKE ; CANCER-CELLS ; TUMOR-LOCALIZATION ; IONIZING-RADIATION ; PROTEIN-KINASE ; IN-VIVO ; ARREST ; THERAPY ; GROWTH ; SIZE
资助项目Key Project of National Natural Science Foundation of China (National Natural Science Foundation of China)[U1232207] ; National Key Technology Support Program of the Ministry of Science and Technology of China (Ministry of Science and Technology of China)[2015BAI01B11] ; National Natural Science Foundation of China[11075191] ; National Natural Science Foundation of China[11205217]
WOS研究方向Oncology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000380075400027
出版者ELSEVIER IRELAND LTD
资助机构Key Project of National Natural Science Foundation of China (National Natural Science Foundation of China) ; National Key Technology Support Program of the Ministry of Science and Technology of China (Ministry of Science and Technology of China) ; National Natural Science Foundation of China
源URL[http://119.78.100.186/handle/113462/43105]  
专题近代物理研究所_先进核能材料研究室（ADS）
通讯作者Li, Qiang
作者单位1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Beijing 100864, Peoples R China
2.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China
3.Natl Ctr Nanosci & Technol China, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Modern Phys, Beijing 100864, Peoples R China
6.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Yan,Chen, Weiqiang,Zhang, Pengcheng,et al. Dynamically-enhanced retention of gold nanoclusters in HeLa cells following X-rays exposure: A cell cycle phase-dependent targeting approach[J]. RADIOTHERAPY AND ONCOLOGY,2016,119:544-551.
APA Liu, Yan.,Chen, Weiqiang.,Zhang, Pengcheng.,Jin, Xiaodong.,Liu, Xinguo.,...&Li, Qiang.(2016).Dynamically-enhanced retention of gold nanoclusters in HeLa cells following X-rays exposure: A cell cycle phase-dependent targeting approach.RADIOTHERAPY AND ONCOLOGY,119,544-551.
MLA Liu, Yan,et al."Dynamically-enhanced retention of gold nanoclusters in HeLa cells following X-rays exposure: A cell cycle phase-dependent targeting approach".RADIOTHERAPY AND ONCOLOGY 119(2016):544-551.

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来源：近代物理研究所

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