Synthesis, Crystal Structure and Biological Evaluation of 14-O-[(2-chloroacetamide-6-aminopyrimidine-2-yl)thioacetyl] Mutilin
文献类型：期刊论文
| 作者 | Zhou Xiang2; Li Xue-Hu2 ; Yi Yun-Peng1; Lu Xi-Hong2; Wang Liang2,3; Liang Jian-Ping2; Shang Ruo-Feng1; Xin Zhi-Jun2
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| 刊名 | CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
 |
| 出版日期 | 2017-08-15 |
| 卷号 | 36页码:1327-1333 |
| 关键词 | pleuromutilin derivative single-crystal structure antibacterial activities |
| ISSN号 | 0254-5861 |
| DOI | 10.14102/j.cnki.0254-5861.2011-1545 |
| 英文摘要 | The title compound 14-O-[(2-chloroacetamide-6-aminopyrimidine-2-yl) thioacetyl] mutilin (4), C28H39ClN4O5S, was prepared and characterized by IR, NMR, HRMS and single- crystal X-ray diffraction. The title compound crystallizes in orthorhombic system, space group P212121 with a = 11.5388(8), b = 14.5282(10), c = 19.8301(14) A, V = 3324.3(4) A(3), Z = 4, D-c = 1.396 g/cm(3), mu(MoK alpha) = 0.462 mm(-1), F(000) = 1464, S = 1.003, R = 0.0386 and wR = 0.1014 for 5170 independent reflections (R-int = 0.0224) with I > 2 sigma(I)). The preliminary in vitro antibacterial bioassay against methicillin-resistant Staphylococcus aureus (MRSA-ATCC25923), Staphylo- coccus aureus (S. aureus), Escherichia coli (E. coli), and Staphylococcus warneri (S .warneri) were screened and the MIC values of the title compound were 0.125, 0.0625, 8 and 0.5 mu g/mL, respectively. |
| WOS关键词 | INFECTIOUS-DISEASES SOCIETY ; PLEUROMUTILIN DERIVATIVES ; ANTIBACTERIAL EVALUATION ; ANTIBIOTICS ; PYRIMIDINE ; AMERICA ; MOIETY |
| 资助项目 | Lanzhou Science and Technology Development[2016-3-101] |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000409181600014 |
| 出版者 | CHINESE JOURNAL STRUCTURAL CHEMISTRY |
| 资助机构 | Lanzhou Science and Technology Development |
| 源URL | [http://119.78.100.186/handle/113462/45659]  |
| 专题 | 近代物理研究所_重离子辐照药物研发中心 |
| 通讯作者 | Liang Jian-Ping |
| 作者单位 | 1.CAAS, Lanzhou Inst Husb & Pharmaceut Sci, Lanzhou 730050, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou Xiang,Li Xue-Hu,Yi Yun-Peng,et al. Synthesis, Crystal Structure and Biological Evaluation of 14-O-[(2-chloroacetamide-6-aminopyrimidine-2-yl)thioacetyl] Mutilin[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,2017,36:1327-1333. |
| APA | Zhou Xiang.,Li Xue-Hu.,Yi Yun-Peng.,Lu Xi-Hong.,Wang Liang.,...&Xin Zhi-Jun.(2017).Synthesis, Crystal Structure and Biological Evaluation of 14-O-[(2-chloroacetamide-6-aminopyrimidine-2-yl)thioacetyl] Mutilin.CHINESE JOURNAL OF STRUCTURAL CHEMISTRY,36,1327-1333. |
| MLA | Zhou Xiang,et al."Synthesis, Crystal Structure and Biological Evaluation of 14-O-[(2-chloroacetamide-6-aminopyrimidine-2-yl)thioacetyl] Mutilin".CHINESE JOURNAL OF STRUCTURAL CHEMISTRY 36(2017):1327-1333. |
入库方式： OAI收割
来源：近代物理研究所
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