Synthesis and antibacterial evaluation of novel pleuromutilin derivatives
文献类型：期刊论文
| 作者 | Liu, Yu2; Guo, Wenzhu2; Guo, Zhiting2; Hao, Baocheng2; Liang Jianping2 ; Shang, Ruofeng2; Xin, Zhijun1
|
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-05-01 |
| 卷号 | 63页码:231-238 |
| 关键词 | Pleuromutilin Derivative Antibacterial Activity Synthesis Antibiotics Acylation Reaction |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2013.01.048 |
| 文献子类 | Article |
| 英文摘要 | A series of novel pleuromutilin derivatives possessing thioether moiety has been synthesized via acylation reaction under mild conditions. Their in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae were tested by agar dilution method and Oxford cup assay. Among the 17 compounds screened, 14-O-[(4-methoxybenzamide-2- methylpropane-2-yl) thioacetate] mutilin 4i, 14-O-[(2-aminobenzamide-2-methylpropane-2-yl) thioacetate] mutilin 5a and 14-O-[(4-aminobenzamide-2-methylpropane-2-yl) thioacetate] mutilin 5c were resulted as most active antibacterial agents. Crown Copyright (C) 2013 Published by Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | TIAMULIN ; RESISTANCE ; RIBOSOME ; ANTIBIOTICS ; RNA ; FIT |
| 资助项目 | "Five-Year" plan of national science and technology projects in rural areas[2011AA10A214] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000322855400024 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.186/handle/113462/48275]  |
| 专题 | 近代物理研究所_重离子辐照药物研发中心 |
| 通讯作者 | Liang Jianping |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Agr Sci, Key Lab New Anim Drug Project, Key Lab Vet Pharmaceut Discovery,Minist Agr, Lanzhou Inst Anim Sci & Vet Pharmaceut Sci, Lanzhou 730050, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yu,Guo, Wenzhu,Guo, Zhiting,et al. Synthesis and antibacterial evaluation of novel pleuromutilin derivatives[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,63:231-238. |
| APA | Liu, Yu.,Guo, Wenzhu.,Guo, Zhiting.,Hao, Baocheng.,Liang Jianping.,...&Xin, Zhijun.(2013).Synthesis and antibacterial evaluation of novel pleuromutilin derivatives.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,63,231-238. |
| MLA | Liu, Yu,et al."Synthesis and antibacterial evaluation of novel pleuromutilin derivatives".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 63(2013):231-238. |
入库方式： OAI收割
来源：近代物理研究所
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