Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus
文献类型：期刊论文
| 作者 | Li Yan1; Wang Xuehong2; Liang Jianping2,4 ; Shang Ruofeng2; Zhou Liye3; Pu Xiuying1
|
| 刊名 | CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 90页码:123-130 |
| 关键词 | Influenza a Virus (Iav) Hypericum Perforatum L. Extract (Hpe) Therapeutic Efficacy Cytokine |
| ISSN号 | 0008-4212 |
| DOI | 10.1139/Y11-111 |
| 文献子类 | Article |
| 英文摘要 | Hypericum perforatum L., a plant used in Chinese herbal medicine, has been proven effective against many viral diseases. In the present study, the therapeutic efficacy of an extract of H. perforatum (HPE) against influenza A virus (IAV) was investigated in mice. Whether HPE would be a promising agent for influenza treatment was evaluated by measuring the protection rate, mean survival days, lung index, and viral titer, as well as the secretion of IL-6, interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in lung tissue and serum on days 3 and 5 post-infection. The results showed that HPE could reduce the lung index and viral titer of mice infected with IAV, decrease mortality, and prolong the mean survival time. HPE decreased the concentration of IL-6 and TNF-alpha in lung tissue and serum on day 5 post-infection. In contrast, HPE enhanced the lung and serum levels of IL-10 and IFN-gamma on the days 3 and 5 post-infection. Our study indicates that HPE has significant therapeutic efficacy for mice infected with IAV. The possible reasons for these results were concluded to be pertaining to up-regulating the expression of IL-10 and IFN-gamma, and down-regulating the secretion of IL-6 and TNF-alpha in lung and serum. |
| WOS关键词 | ANTHRAQUINONE DERIVATIVES ; PATHOGENESIS ; ENCEPHALOPATHY ; CYTOKINES ; INTERFERON ; MECHANISM ; DISEASE ; IL-6 |
| 资助项目 | Chinese Academy of Sciences[O861010ZY0] |
| WOS研究方向 | Pharmacology & Pharmacy ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000300617800001 |
| 出版者 | CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS |
| 源URL | [http://119.78.100.186/handle/113462/49105]  |
| 专题 | 近代物理研究所_重离子辐照药物研发中心 |
| 通讯作者 | Pu Xiuying |
| 作者单位 | 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 2.Chinese Acad Agr Sci, Lanzhou Inst Anim Sci & Vet Pharmaceut, Key Lab New Anim Drug Project Gansu Prov, Key Lab New Anim Drug Project CAAS, Lanzhou 730050, Peoples R China 3.Inner Mongolia Univ Nationalities, Tongliao 028043, Peoples R China 4.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Yan,Wang Xuehong,Liang Jianping,et al. Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,2012,90:123-130. |
| APA | Li Yan,Wang Xuehong,Liang Jianping,Shang Ruofeng,Zhou Liye,&Pu Xiuying.(2012).Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus.CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,90,123-130. |
| MLA | Li Yan,et al."Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus".CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 90(2012):123-130. |
入库方式： OAI收割
来源：近代物理研究所
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