Study on N-(pyridin-4-yl) salicylamides as Antimycobacterial Agents
文献类型：会议论文
| 作者 | Kong, JY; Zhu, HX; Zeng, JM; Lu, Xihong ; Li, Xuehu; Xin, Zhijun; Tao, Lei; Liang, Jianping; He, Dian; Jia, Zhong
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| 出版日期 | 2013 |
| 关键词 | Mycobacterium tuberculosis N-(pyridin-4-yl) salicylamides Activity evaluation Synthesis |
| 卷号 | 634-638 |
| DOI | 10.4028/www.scientific.net/AMR.634-638.1371 |
| 页码 | 1371-1375 |
| 英文摘要 | A series of N-(pyridin-4-yl) salicylamides derivatives were prepared through acylation of the corresponding acetylsalicyloyl chlorides with substituted 4-amino-pyridines. These compounds were evaluated in vitro for antimycobacterial activities against Mycobacterium tuberculosis (TB) and Mycobacterium avium (A) by the minimum inhibitory concentrations (MIC) values. Eight of the compounds exhibited lower MIC against A than isoniazide (INH). Meanwhile, four of the compounds exhibited good anti-TB activity, when they were compared with INH. Antimycobacterial activities of N-(pyridin-4-yl) salicylamides were influenced by the balance between hydrophobicity and electron-withdrawing substituent effect on the phenyl and pyridine ring. These studies show that these compounds might serve as prospective wide-spectrum antimycobacterial substances. |
| 会议录 | ADVANCES IN CHEMICAL, MATERIAL AND METALLURGICAL ENGINEERING, PTS 1-5
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| 会议录出版者 | TRANS TECH PUBLICATIONS LTD |
| 会议录出版地 | LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND |
| 语种 | 英语 |
| WOS研究方向 | Engineering ; Materials Science ; Metallurgy & Metallurgical Engineering |
| WOS记录号 | WOS:000322420400266 |
| 源URL | [http://119.78.100.186/handle/113462/58007]  |
| 专题 | 近代物理研究所_重离子辐照药物研发中心 |
| 通讯作者 | Xin, Zhijun |
| 作者单位 | Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, JY,Zhu, HX,Zeng, JM,et al. Study on N-(pyridin-4-yl) salicylamides as Antimycobacterial Agents[C]. 见:. |
入库方式： OAI收割
来源：近代物理研究所
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