Preparation, characterization and in vitro evaluation of IVM loaded poly(lactic-co-glycolic acid) (PLGA) microspheres
文献类型：会议论文
| 作者 | Li, Guiyu1,2; Lu, Xihong2 ; Li, Xuehu2; Tao, Lei2; Liang, Jianping2; Guo, ZN
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| 出版日期 | 2011 |
| 关键词 | microspheres S/O/W emulsion IVM-PLGA-MS particle size distribution in vitro release |
| 卷号 | 311-313 |
| DOI | 10.4028/www.scientific.net/AMR.311-313.1751 |
| 页码 | 1751-+ |
| 英文摘要 | Drug was encapsulated in a novel copolymers of poly(lactic-co-glycolic acid) (PLGA) to investigate the sustained-release formulation of drug loaded polymer microspheres delivery system. Used a modified solid-in-oil-in-water (S/O/W) emulsion solvent evaporation method to prepare microspheres, its morphology and particle size distribution were estimated by scanning electron microscopy (SEM), the profile of in vitro drug release were assessed by High performance liquid chromatography (HPLC). Finally, an stable release buffer was utilized to obtain a detailed drug release profile, which was analyzed by HPLC also. Results showed that the microspheres morphology, encapsulation efficiency and the cumulative drug release efficiency were appropriate for veterinary medicine using. The modified preparation method was simple and optimized, PLGA microspheres with excellent controlled-release characteristics may serve as drug delivery carrier and may prolong the drug sustained-release effect. |
| 会议录 | ADVANCED MATERIALS AND PROCESSES, PTS 1-3
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| 会议录出版者 | TRANS TECH PUBLICATIONS LTD |
| 会议录出版地 | KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND |
| 语种 | 英语 |
| 资助项目 | Key scientific technology research project of Gansu province[092GKDA0033] |
| WOS研究方向 | Materials Science |
| WOS记录号 | WOS:000309144500351 |
| 源URL | [http://119.78.100.186/handle/113462/58498]  |
| 专题 | 近代物理研究所_重离子辐照药物研发中心 |
| 通讯作者 | Li, Guiyu |
| 作者单位 | 1.Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Guiyu,Lu, Xihong,Li, Xuehu,et al. Preparation, characterization and in vitro evaluation of IVM loaded poly(lactic-co-glycolic acid) (PLGA) microspheres[C]. 见:. |
入库方式： OAI收割
来源：近代物理研究所
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