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6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda

文献类型：期刊论文

作者Wang, Jiajia7; Chen, Dahua6,8; Sun, Qinmiao6,8; Tao, Yi4; He, Chuan1,2; Zhao, Yi3; Zhang, Peng7; Zhang, Wenxin5,8; Wang, Xiaona8; Luo, Yuewan6,8
刊名NATURE COMMUNICATIONS
出版日期2019-05-17
卷号10页码:14
ISSN号2041-1723
DOI10.1038/s41467-019-10202-3
英文摘要A long-standing question in the field of embryogenesis is how the zygotic genome is precisely activated by maternal factors, allowing normal early embryonic development. We have previously shown that N6-methyladenine (6mA) DNA modification is highly dynamic in early Drosophila embryos and forms an epigenetic mark. However, little is known about how 6mA-formed epigenetic information is decoded. Here we report that the Fox-family protein Jumu binds 6mA-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition. We find that zelda encoding the pioneer factor Zelda is marked by 6mA. Our genetic assays suggest that Jumu controls the proper zygotic genome activation (ZGA) in early embryos, at least in part, by regulating zelda expression. Thus, our findings not only support that the 6mA-formed epigenetic marks can be read by specific transcription factors, but also uncover a mechanism by which the Jumu regulates ZGA partially through Zelda in early embryos.
资助项目Ministry of Science and Technology of China[2016YFA0100400] ; Ministry of Science and Technology of China[2018YFC1003300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13000000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000] ; Natural Science Foundation of China[31590831] ; Natural Science Foundation of China[31671498] ; Natural Science Foundation of China[31871294] ; National Key R&D Program of China[2017YFA0506800] ; National Key R&D Program of China[2016YFC0901700] ; CAS Interdisciplinary Innovation Team
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000468174600019
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.204/handle/2XEOYT63/4225]  
专题中国科学院计算技术研究所期刊论文_英文
通讯作者Chen, Dahua; Sun, Qinmiao
作者单位1.Univ Chicago, Howard Hughes Med Inst, Inst Biophys Dynam, 5841 S Maryland Ave, Chicago, IL 60637 USA
2.Univ Chicago, Howard Hughes Med Inst, Dept Chem, 5841 S Maryland Ave, Chicago, IL 60637 USA
3.Chinese Acad Sci, Adv Comp Res Ctr, Inst Comp Technol, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Ctr Computat & Evolutionary Biol, Beijing 100101, Peoples R China
5.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China
6.Univ Chinese Acad Sci, Sch Life Sci, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Ctr Big Data Res Hlth, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China
8.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Jiajia,Chen, Dahua,Sun, Qinmiao,et al. 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda[J]. NATURE COMMUNICATIONS,2019,10:14.
APA Wang, Jiajia.,Chen, Dahua.,Sun, Qinmiao.,Tao, Yi.,He, Chuan.,...&He, Shunmin.(2019).6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda.NATURE COMMUNICATIONS,10,14.
MLA Wang, Jiajia,et al."6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda".NATURE COMMUNICATIONS 10(2019):14.

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来源：计算技术研究所

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