Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression
文献类型：期刊论文
| 作者 | Ning, Junya2,3; Zhao, Yi1; Ye, Yingnan3; Yu, Jinpu2,3 |
| 刊名 | EBIOMEDICINE
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 41页码:702-710 |
| 关键词 | TGF-beta BMP cancer antagonistic potential mechanism |
| ISSN号 | 2352-3964 |
| DOI | 10.1016/j.ebiom.2019.02.033 |
| 英文摘要 | The transforming growth factor beta (TGF-beta) superfamily participates in tumour proliferation, apoptosis, differentiation, migration, invasion, immune evasion and extracellular matrix remodelling. Genetic deficiency in distinct components of TGF-beta and BMP-induced signalling pathways or their excessive activation has been reported to regulate the development and progression of some cancers. As more in-depth studies about this superfamily have been conducted, more evidence suggests that the TGF-beta and BMP pathways play an opposing role. The cross-talk of these 2 pathways has been widely studied in kidney disease and bone formation, and the opposing effects have also been observed in some cancers. However, the antagonistic mechanisms are still insufficiently investigated in cancer. In this review, we aim to display more evidences and possible mechanisms accounting for the antagonism between these 2 pathways, which might provide some clues for further study in cancer. (c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://reativecommons.org/licenses/by-nc-nd/4.0/). |
| 资助项目 | National Natural Science Foundation of China[81872143,81472473] ; National Natural Science Foundation of China[81702280] ; National Natural Science Foundation of China[81272360] ; Key Project of Tianjin Health and Family Planning Commission[16KG126] |
| WOS研究方向 | General & Internal Medicine ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000464321900080 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.204/handle/2XEOYT63/4265]  |
| 专题 | 中国科学院计算技术研究所期刊论文_英文 |
| 通讯作者 | Yu, Jinpu |
| 作者单位 | 1.Chinese Acad Sci, Inst Comp Technol, State Key Lab Comp Architecture, Key Lab Intelligent Informat Proc,Adv Comp Res Ct, Beijing, Peoples R China 2.Tianjin Med Univ Canc Inst & Hosp, Dept Immunol, Natl Clin Res Ctr Canc, Key Lab Canc Immunol & Biotherapy,Tianjins Clin R, Tianjin, Peoples R China 3.Tianjin Med Univ Canc Inst & Hosp, Canc Mol Diagnost Core, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy,Tianjins Clin Res, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ning, Junya,Zhao, Yi,Ye, Yingnan,et al. Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression[J]. EBIOMEDICINE,2019,41:702-710. |
| APA | Ning, Junya,Zhao, Yi,Ye, Yingnan,&Yu, Jinpu.(2019).Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression.EBIOMEDICINE,41,702-710. |
| MLA | Ning, Junya,et al."Opposing roles and potential antagonistic mechanism between TGF-beta and BMP pathways: Implications for cancer progression".EBIOMEDICINE 41(2019):702-710. |
入库方式： OAI收割
来源：计算技术研究所
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